{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:05:36Z","timestamp":1791986736151,"version":"4.4.0"},"reference-count":72,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"31","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,8,4]]},"abstract":"<jats:p>Human cardiac organoids hold remarkable potential for cardiovascular disease modeling and human pluripotent stem cell\u2013derived cardiomyocyte (hPSC-CM) transplantation. Here, we show cardiac organoids engineered with electrically conductive silicon nanowires (e-SiNWs) significantly enhance the therapeutic efficacy of hPSC-CMs to treat infarcted hearts. We first demonstrated the biocompatibility of e-SiNWs and their capacity to improve cardiac microtissue engraftment in healthy rat myocardium. Nanowired human cardiac organoids were then engineered with hPSC-CMs, nonmyocyte supporting cells, and e-SiNWs. Nonmyocyte supporting cells promoted greater ischemia tolerance of cardiac organoids, and e-SiNWs significantly improved electrical pacing capacity. After transplantation into ischemia\/reperfusion\u2013injured rat hearts, nanowired cardiac organoids significantly improved contractile development of engrafted hPSC-CMs, induced potent cardiac functional recovery, and reduced maladaptive left ventricular remodeling. Compared to contemporary studies with an identical injury model, greater functional recovery was achieved with a 20-fold lower dose of hPSC-CMs, revealing therapeutic synergy between conductive nanomaterials and human cardiac organoids for efficient heart repair.<\/jats:p>","DOI":"10.1126\/sciadv.adf2898","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T17:58:23Z","timestamp":1691171903000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":60,"title":["Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-9179","authenticated-orcid":true,"given":"Yu","family":"Tan","sequence":"first","affiliation":[{"name":"Bioengineering Department, Clemson University, Clemson, SC 29634, 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