{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:07:26Z","timestamp":1792570046471,"version":"4.5.0"},"reference-count":42,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"27","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,7,7]]},"abstract":"<jats:p>\n                    Oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) sensing by the carotid body is critical for maintaining cardiorespiratory homeostasis during hypoxia. Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) signaling is implicated in carotid body activation by low O\n                    <jats:sub>2<\/jats:sub>\n                    . Here, we show that persulfidation of olfactory receptor 78 (Olfr78) by H\n                    <jats:sub>2<\/jats:sub>\n                    S is an integral component of carotid body activation by hypoxia. Hypoxia and H\n                    <jats:sub>2<\/jats:sub>\n                    S increased persulfidation in carotid body glomus cells and persulfidated cysteine\n                    <jats:sup>240<\/jats:sup>\n                    in Olfr78 protein in heterologous system.\n                    <jats:italic>Olfr78<\/jats:italic>\n                    mutants manifest impaired carotid body sensory nerve, glomus cell, and breathing responses to H\n                    <jats:sub>2<\/jats:sub>\n                    S and hypoxia. Glomus cells are positive for G\n                    <jats:sub>Olf,<\/jats:sub>\n                    adenylate cyclase 3 (Adcy3) and cyclic nucleotide\u2013gated channel alpha 2 (Cnga2), key molecules of odorant receptor signaling.\n                    <jats:italic>Adcy3<\/jats:italic>\n                    or\n                    <jats:italic>Cnga2<\/jats:italic>\n                    mutants exhibited impaired carotid body and glomus cell responses to H\n                    <jats:sub>2<\/jats:sub>\n                    S and breathing responses to hypoxia. These results suggest that H\n                    <jats:sub>2<\/jats:sub>\n                    S through redox modification of Olfr78 participates in carotid body activation by hypoxia to regulate breathing.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adf3026","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:57:39Z","timestamp":1688565459000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":29,"title":["Hypoxia sensing requires H\n                    <sub>2<\/sub>\n                    S-dependent persulfidation of olfactory receptor 78"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-5198","authenticated-orcid":true,"given":"Ying-Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Institute for Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasri","family":"Nanduri","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh K.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-2284","authenticated-orcid":true,"given":"Vytautas","family":"Bindokas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacological Sciences, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6103","authenticated-orcid":true,"given":"Bindu D.","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The Johns Hopkins University, Baltimore, MD, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-8510","authenticated-orcid":true,"given":"Xuanmao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Biomedical Sciences, College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron P.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacological Sciences, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3377-3187","authenticated-orcid":true,"given":"Thibaut","family":"Vignane","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Analytische Wissenschaften\u2013ISAS, Bunsen-Kirchhoff-Stra\u00dfe, 1144139 Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos R.","family":"Filipovic","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Analytische Wissenschaften\u2013ISAS, Bunsen-Kirchhoff-Stra\u00dfe, 1144139 Dortmund, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4570-1380","authenticated-orcid":true,"given":"Nanduri R.","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Institute for Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100069"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2019"},{"key":"e_1_3_3_4_2","first-page":"F1000 Faculty R","volume":"7","author":"Prabhakar N. 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