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In an independent dataset, the TRN model predicted target gene expression with an out-of-sample\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    greater than 0.25 for 73% of target genes. We performed siRNA knockdowns of four TFs and achieved concordance between the predicted gene targets in our TRN and differences in expression of knockdowns with an accuracy of &gt;0.7 for three of the four TFs. Our final model contained 113,158 interactions across 391 TFs and 7712 target genes and is publicly available. We identified 29 TFs which were significantly enriched as regulators for genes previously associated with preterm birth, and eight of these TFs were decreased in preterm placentas.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adf3411","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:59:32Z","timestamp":1719583172000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":19,"title":["A genome scale transcriptional regulatory model of the human placenta"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-9398","authenticated-orcid":true,"given":"Alison","family":"Paquette","sequence":"first","affiliation":[{"name":"University of Washington, Seattle, WA, USA."},{"name":"Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5395-1091","authenticated-orcid":true,"given":"Kylia","family":"Ahuna","sequence":"additional","affiliation":[{"name":"Oregon Health and Sciences University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-8623","authenticated-orcid":true,"given":"Yeon Mi","family":"Hwang","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-9699","authenticated-orcid":true,"given":"Jocelynn","family":"Pearl","sequence":"additional","affiliation":[{"name":"Tune Therapeutics, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-7990","authenticated-orcid":true,"given":"Hanna","family":"Liao","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6641-3115","authenticated-orcid":true,"given":"Paul","family":"Shannon","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-5210","authenticated-orcid":true,"given":"Leena","family":"Kadam","sequence":"additional","affiliation":[{"name":"Oregon Health and Sciences University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-7633","authenticated-orcid":true,"given":"Samantha","family":"Lapehn","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Research Institute, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9012-6229","authenticated-orcid":true,"given":"Matthew","family":"Bucher","sequence":"additional","affiliation":[{"name":"Oregon Health and Sciences University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-7029","authenticated-orcid":true,"given":"Ryan","family":"Roper","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-9011","authenticated-orcid":true,"given":"Cory","family":"Funk","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-7626","authenticated-orcid":true,"given":"James","family":"MacDonald","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-2825","authenticated-orcid":true,"given":"Theo","family":"Bammler","sequence":"additional","affiliation":[{"name":"University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-4941","authenticated-orcid":true,"given":"Priyanka","family":"Baloni","sequence":"additional","affiliation":[{"name":"Institute for Systems Biology, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Brockway","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida, Gainesville, FL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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