{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:37:58Z","timestamp":1790739478077,"version":"4.1.0"},"reference-count":65,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,1,27]]},"abstract":"<jats:p>Measles virus (MeV), which is usually non-neurotropic, sometimes persists in the brain and causes subacute sclerosing panencephalitis (SSPE) several years after acute infection, serving as a model for persistent viral infections. The persisting MeVs have hyperfusogenic mutant fusion (F) proteins that likely enable cell-cell fusion at synapses and \u201cen bloc transmission\u201d between neurons. We here show that during persistence, F protein fusogenicity is generally enhanced by cumulative mutations, yet mutations paradoxically reducing the fusogenicity may be selected alongside the wild-type (non-neurotropic) MeV genome. A mutant F protein having SSPE-derived substitutions exhibits lower fusogenicity than the hyperfusogenic F protein containing some of those substitutions, but by the wild-type F protein coexpression, the fusogenicity of the former F protein is enhanced, while that of the latter is nearly abolished. These findings advance the understanding of the long-term process of MeV neuropathogenicity and provide critical insight into the genotype-phenotype relationships of en bloc transmitted viruses.<\/jats:p>","DOI":"10.1126\/sciadv.adf3731","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T19:02:24Z","timestamp":1674846144000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":31,"title":["Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-0310","authenticated-orcid":true,"given":"Yuta","family":"Shirogane","sequence":"first","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1498-8147","authenticated-orcid":true,"given":"Hidetaka","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tateki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-7571","authenticated-orcid":true,"given":"Takao","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yanagi","sequence":"additional","affiliation":[{"name":"National Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.05023-11"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.022"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2019.02.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.02.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2019.03.023"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.09.012"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27293-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/v9010011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14166"},{"key":"e_1_3_3_11_2","unstructured":"D.\u00a0E.\u00a0Griffin Measles virus in Fields Virology D.\u00a0M.\u00a0Knipe P.\u00a0M.\u00a0Howley Eds. 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