{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:52:54Z","timestamp":1792641174266,"version":"4.5.0"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"24","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:p>Viral infections continue to threaten human health. It remains a major challenge to efficiently inhibit viral infection while avoiding secondary injury. Here, we designed a multifunctional nanoplatform (termed as ODCM), prepared by oseltamivir phosphate (OP)\u2013loaded polydopamine (PDA) nanoparticles camouflaged by the macrophage cell membrane (CM). OP can be efficiently loaded onto the PDA nanoparticles through the \u03c0-\u03c0 stacking and hydrogen bonding interactions with a high drug-loading rate of 37.6%. In particular, the biomimetic nanoparticles can accumulate actively in the damaged lung model of viral infection. At the infection site, PDA nanoparticles can consume excess reactive oxygen species and be simultaneously oxidized and degraded to achieve controlled release of OP. This system exhibits enhanced delivery efficiency, inflammatory storm suppression, and viral replication inhibition. Therefore, the system exerts outstanding therapeutic effects while improving pulmonary edema and protecting lung injury in a mouse model of influenza A virus infection.<\/jats:p>","DOI":"10.1126\/sciadv.adf4098","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T17:57:40Z","timestamp":1686765460000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":68,"title":["Polydopamine-based nanomedicines for efficient antiviral and secondary injury protection therapy"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-2837","authenticated-orcid":true,"given":"Na","family":"Yin","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China."},{"name":"Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China."},{"name":"Key Laboratory of Key Drug 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China."},{"name":"Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China."},{"name":"Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou 450001, China."},{"name":"State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou 450001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1531-7265","authenticated-orcid":true,"given":"Jinjin","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China."},{"name":"Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China."},{"name":"Key Laboratory of Key Drug Preparation Technology Ministry of Education, Zhengzhou 450001, China."},{"name":"State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou 450001, 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