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During cued fear conditioning, freezing behavior was enhanced in female, but not male, cocaine-sired progeny. In contrast, male cocaine-sired progeny exhibited enhanced expression of cue-conditioned fear during extinction. Long-term potentiation (LTP) was robust in the basolateral amygdala (BLA), which encodes fear conditioning, of female offspring but was completely absent in male offspring of cocaine-exposed sires. Collectively, these results indicate that cued fear memory is enhanced in the male progeny of cocaine exposed sires, which also have BLA synaptic plasticity deficits.<\/jats:p>","DOI":"10.1126\/sciadv.adf6039","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T17:58:36Z","timestamp":1697651916000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Sex-dependent fear memory impairment in cocaine-sired rat offspring"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7192-6327","authenticated-orcid":true,"given":"Matthew T.","family":"Rich","sequence":"first","affiliation":[{"name":"Brain Health Institute and Department of Psychiatry, Rutgers University, Piscataway, NJ 08854 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2840-8174","authenticated-orcid":true,"given":"Samantha J.","family":"Worobey","sequence":"additional","affiliation":[{"name":"Brain Health Institute and Department of Psychiatry, Rutgers University, Piscataway, NJ 08854 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-0140","authenticated-orcid":true,"given":"Sharvari","family":"Mankame","sequence":"additional","affiliation":[{"name":"Brain Health Institute and Department of Psychiatry, Rutgers University, Piscataway, NJ 08854 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-1233","authenticated-orcid":true,"given":"Zhiping P.","family":"Pang","sequence":"additional","affiliation":[{"name":"Child Health Institute and Department of Neuroscience &amp; Cell Biology, Rutgers University, New Brunswick, NJ 08901, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-2939","authenticated-orcid":true,"given":"Sarah E.","family":"Swinford-Jackson","sequence":"additional","affiliation":[{"name":"Brain Health Institute and Department of Psychiatry, Rutgers University, Piscataway, NJ 08854 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5189","authenticated-orcid":true,"given":"R. 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