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We present a method for VTA treatment based on subthreshold electrical stimulations using a stretchable epicardial multichannel electrode array, which does not disturb the normal contraction or electrical propagation of the ventricle. In rabbit models with myocardial infarction, the infarction was detected by mapping intracardiac electrograms with the stretchable epicardial multichannel electrode array. Then, VTAs could be terminated by sequential electrical stimuli from the epicardial multichannel electrode array beginning with low-energy subthreshold stimulations. Last, we used these subthreshold stimulations to prevent the occurrence of additional VTAs. The proposed protocol using the stretchable epicardial multichannel electrode array provides opportunities toward the development of innovative methods for painless ICD therapy.<\/jats:p>","DOI":"10.1126\/sciadv.adf6856","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T13:59:37Z","timestamp":1680271177000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":52,"title":["Ventricular tachyarrhythmia treatment and prevention by subthreshold stimulation with stretchable epicardial multichannel electrode array"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3925-1275","authenticated-orcid":true,"given":"Sung-Hyuk","family":"Sunwoo","sequence":"first","affiliation":[{"name":"Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea."},{"name":"School of Chemical and Biological Engineering and Institute of Chemical 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