{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:22:21Z","timestamp":1777580541833,"version":"3.51.4"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"45","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,11,10]]},"abstract":"<jats:p>\n                    Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients\u2019 plasma for 66 immune-related factors in patients with sporadic VS (\n                    <jats:italic>N<\/jats:italic>\n                    &gt; 170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a nine-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, and S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adf7295","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T13:58:41Z","timestamp":1699624721000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3923-3448","authenticated-orcid":true,"given":"Sasa","family":"Vasilijic","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA."},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia A.","family":"Atai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-7796","authenticated-orcid":true,"given":"Hiroshi","family":"Hyakusoku","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."},{"name":"Department of Otorhinolaryngology, Yokosuka Kyosai Hospital, Kanagawa, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9550-5797","authenticated-orcid":true,"given":"Steven","family":"Worthington","sequence":"additional","affiliation":[{"name":"Harvard Institute for Quantitative Social Science, Harvard University, Cambridge, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-524X","authenticated-orcid":true,"given":"Jessica E.","family":"Sagers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-1448","authenticated-orcid":true,"given":"Mehmet I.","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-8818","authenticated-orcid":true,"given":"Alyssa","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charvi","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-6231","authenticated-orcid":true,"given":"Takeshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-2625","authenticated-orcid":true,"given":"Lukas D.","family":"Landegger","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-3658","authenticated-orcid":true,"given":"Richard","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA."},{"name":"Department of Neurology, Harvard Medical School, Boston, MA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-469X","authenticated-orcid":true,"given":"D. 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