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CHEK2 activates two downstream targets\u2014TAp63 and p53\u2014which direct oocyte elimination. CHEK2 knockout or pharmacological inhibition preserved ovarian follicle reserve after radiation and chemotherapy. However, the lack of specificity for CHEK2 among available inhibitors limits their potential for clinical development. These findings demonstrate that CHEK2 is a master regulator of the ovarian cellular response to damage caused by radiation and chemotherapy and warrant the development of selective inhibitors specific to CHEK2 as a potential avenue for ovario-protective treatments.<\/jats:p>","DOI":"10.1126\/sciadv.adg0898","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T13:58:51Z","timestamp":1697810331000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":31,"title":["CHEK2 signaling is the key regulator of oocyte survival after chemotherapy"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-2517","authenticated-orcid":true,"given":"Chihiro","family":"Emori","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA."},{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Boucher","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-6670","authenticated-orcid":true,"given":"Ewelina","family":"Bolcun-Filas","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/RAF-22-0020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.11.032"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1839"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.11.006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3723"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1914"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.06.029"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2020.11.009"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.08.034"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-019-00066-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hox001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det391"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.05.040"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab012"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.01.012"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235714"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402052"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247671"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-380888-2.00003-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-020-00089-x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0035-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0633-7"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0151-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0370"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.203455"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz027"},{"key":"e_1_3_2_29_2","first-page":"2783","article-title":"Mafosfamide as a new anticancer agent: Preclinical investigations and clinical trials","volume":"32","author":"Mazur L.","year":"2012","unstructured":"L.\u00a0Mazur, M.\u00a0Opydo-Chanek, M.\u00a0Stojak, K.\u00a0Wojcieszek, Mafosfamide as a new anticancer agent: Preclinical investigations and clinical trials. 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