{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:03:31Z","timestamp":1792123411660,"version":"4.4.0"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"20","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:p>\n            Molecular therapeutics are limited for\n            <jats:italic>Candida<\/jats:italic>\n            vaginitis because they damage normal cells and tissues of vagina, aggravating the imbalance of vaginal microbiota and increasing the recurrence. To tackle this limitation, through the combination of peroxidase-like rGO@FeS\n            <jats:sub>2<\/jats:sub>\n            nanozymes [reduced graphene oxide (rGO)] with\n            <jats:italic>Lactobacillus<\/jats:italic>\n            -produced lactic acid and H\n            <jats:sub>2<\/jats:sub>\n            O\n            <jats:sub>2<\/jats:sub>\n            , a responsive hyaluronic acid (HA) hydrogel rGO@FeS\n            <jats:sub>2<\/jats:sub>\n            \/\n            <jats:italic>Lactobacillus<\/jats:italic>\n            @HA (FeLab) is developed. FeLab has simultaneous anti\u2013\n            <jats:italic>Candida albicans<\/jats:italic>\n            and vaginal microbiota\u2013modulating activities. In particular, the hydroxyl radical produced from rGO@FeS\n            <jats:sub>2<\/jats:sub>\n            nanozymes and\n            <jats:italic>Lactobacillus<\/jats:italic>\n            kills\n            <jats:italic>C. albicans<\/jats:italic>\n            isolated from clinical specimens without affecting\n            <jats:italic>Lactobacillus<\/jats:italic>\n            . In mice with\n            <jats:italic>Candida<\/jats:italic>\n            vaginitis, FeLab has obvious anti\u2013\n            <jats:italic>C. albicans<\/jats:italic>\n            activity but hardly damages vaginal mucosa cells, which is beneficial to vaginal mucosa repair. Moreover, a higher proportion of\n            <jats:italic>Firmicutes<\/jats:italic>\n            (especially\n            <jats:italic>Lactobacillus<\/jats:italic>\n            ) and a decrease in\n            <jats:italic>Proteobacteria<\/jats:italic>\n            reshape a healthy vaginal microbiota to reduce the recurrence. These results provide a combined therapeutic of nanozymes and probiotics with translational promise for\n            <jats:italic>Candida<\/jats:italic>\n            vaginitis therapy.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adg0949","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T17:57:16Z","timestamp":1684346236000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":133,"title":["A probiotic nanozyme hydrogel regulates vaginal microenvironment for\n            <i>Candida<\/i>\n            vaginitis therapy"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-8565","authenticated-orcid":true,"given":"Gen","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, 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