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We designed a nucleoside-modified mRNA-LNP vaccine based on the bacterial F1 capsule antigen, a major protective component of\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    , the etiological agent of plague. Plague is a rapidly deteriorating contagious disease that has killed millions of people during the history of humankind. Now, the disease is treated effectively with antibiotics; however, in the case of a multiple-antibiotic-resistant strain outbreak, alternative countermeasures are required. Our mRNA-LNP vaccine elicited humoral and cellular immunological responses in C57BL\/6 mice and conferred rapid, full protection against lethal\n                    <jats:italic>Y. pestis<\/jats:italic>\n                    infection after a single dose. These data open avenues for urgently needed effective antibacterial vaccines.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adg1036","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T13:57:16Z","timestamp":1678283836000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":93,"title":["A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3459-7576","authenticated-orcid":true,"given":"Edo","family":"Kon","sequence":"first","affiliation":[{"name":"Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S.\u00a0Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel."},{"name":"Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 69978, Israel."},{"name":"Department of Materials Sciences 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