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RNA sequencing of CD3\n            <jats:sup>+<\/jats:sup>\n            T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adg1610","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:58:21Z","timestamp":1692986301000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-0550","authenticated-orcid":true,"given":"Carlos J.","family":"Gallardo-Dodd","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8913-6358","authenticated-orcid":true,"given":"Christian","family":"Oertlin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-2916","authenticated-orcid":true,"given":"Julien","family":"Record","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-375X","authenticated-orcid":true,"given":"R\u00f4mulo G.","family":"Galvani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil."},{"name":"Universidade Veiga de Almeida, Rio de Janeiro, Brazil."},{"name":"Laboratory for Thymus Research (LPT), Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-7172","authenticated-orcid":true,"given":"Christian","family":"Sommerauer","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-3927","authenticated-orcid":true,"given":"Nikolai V.","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."},{"name":"Russian Federation State Research Center Institute of Biomedical Problems RAS, Moscow, Russia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Doukoumopoulos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaqat","family":"Ali","sequence":"additional","affiliation":[{"name":"Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi (NYUAD), Abu Dhabi, United Arab Emirates."},{"name":"Core Technology Platform, NYUAD, Abu Dhabi, United Arab Emirates."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-1213","authenticated-orcid":true,"given":"Mariana M. 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