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We previously showed that partial loss of\n            <jats:italic>Atoh1<\/jats:italic>\n            function in mice results in delayed PN development and impaired motor learning. In this study, we performed single-cell RNA sequencing to elucidate the cell state\u2013specific functions of\n            <jats:italic>Atoh1<\/jats:italic>\n            during PN development and found that\n            <jats:italic>Atoh1<\/jats:italic>\n            regulates cell cycle exit, differentiation, migration, and survival of PN neurons. Our data revealed six previously not known PN subtypes that are molecularly and spatially distinct. We found that the PN subtypes exhibit differential vulnerability to partial loss of\n            <jats:italic>Atoh1<\/jats:italic>\n            function, providing insights into the prominence of PN phenotypes in patients with\n            <jats:italic>ATOH1<\/jats:italic>\n            missense mutations.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adg1671","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T17:58:21Z","timestamp":1688147901000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["<i>Atoh1<\/i>\n            drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-2996","authenticated-orcid":true,"given":"Sih-Rong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, TX, 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