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GDE3 is expressed in astrocytes but not neurons, yet mice lacking GDE3 [\n            <jats:italic>Gde3<\/jats:italic>\n            knockout (KO)] have decreased miniature excitatory postsynaptic current (mEPSC) amplitudes in hippocampal CA1 neurons. EVs from cultured wild-type astrocytes restore mEPSC amplitudes in\n            <jats:italic>Gde3<\/jats:italic>\n            KOs, while EVs from\n            <jats:italic>Gde3<\/jats:italic>\n            KO astrocytes or astrocytes inhibited for WAVE3 actin branching activity do not. Thus, GDE3-WAVE3 is a nonredundant astrocytic pathway that remodels actin to release a functionally distinct EV subtype, supporting the concept that independent regulation of global EV release pathways differentially regulates EV signaling within the cellular EV landscape.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adg2067","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T18:10:27Z","timestamp":1687543827000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":17,"title":["An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-2947","authenticated-orcid":true,"given":"Reuben","family":"Levy-Myers","sequence":"first","affiliation":[{"name":"The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB1004, 725 N.\u00a0Wolfe Street, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-6423","authenticated-orcid":true,"given":"Daniel","family":"Daudelin","sequence":"additional","affiliation":[{"name":"The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB1004, 725 N.\u00a0Wolfe Street, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-2938","authenticated-orcid":true,"given":"Chan Hyun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, MRB 706, 733 N.\u00a0Broadway, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4147-4782","authenticated-orcid":true,"given":"Shanthini","family":"Sockanathan","sequence":"additional","affiliation":[{"name":"The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, PCTB1004, 725 N.\u00a0Wolfe Street, Baltimore, MD 21205, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23708"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800394"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21420"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04234-3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0369-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003505"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153124"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.09.059"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.02.013"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.02.027"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050443"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.180695"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23649"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015278"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158761"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091955"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.029"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/20013078.2018.1535750"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb1244"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102394"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.021"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh2169"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59928"},{"key":"e_1_3_3_27_2","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1002\/cpns.71","article-title":"Magnetic cell sorting for in vivo and in vitro astrocyte, neuron, and microglia analysis","volume":"88","author":"Holt L. 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