{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:46:33Z","timestamp":1791855993468,"version":"4.3.4"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"41","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:p>Brain cells are arranged in laminar, nuclear, or columnar structures, spanning a range of scales. Here, we construct a reliable cell census in the frontal lobe of human cerebral cortex at micrometer resolution in a magnetic resonance imaging (MRI)\u2013referenced system using innovative imaging and analysis methodologies. MRI establishes a macroscopic reference coordinate system of laminar and cytoarchitectural boundaries. Cell counting is obtained with a digital stereological approach on the 3D reconstruction at cellular resolution from a custom-made inverted confocal light-sheet fluorescence microscope (LSFM). Mesoscale optical coherence tomography enables the registration of the distorted histological cell typing obtained with LSFM to the MRI-based atlas coordinate system. The outcome is an integrated high-resolution cellular census of Broca\u2019s area in a human postmortem specimen, within a whole-brain reference space atlas.<\/jats:p>","DOI":"10.1126\/sciadv.adg3844","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T17:57:22Z","timestamp":1697133442000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":35,"title":["A cellular resolution atlas of Broca\u2019s area"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8464-7324","authenticated-orcid":true,"given":"Irene","family":"Costantini","sequence":"first","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"Department of Biology, University of Florence, Florence, Italy."},{"name":"National Institute of Optics (INO), National Research Council (CNR), Sesto Fiorentino, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6859-734X","authenticated-orcid":true,"given":"Leah","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-9978","authenticated-orcid":true,"given":"Yael","family":"Balbastre","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-9739","authenticated-orcid":true,"given":"Divya","family":"Varadarajan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-399X","authenticated-orcid":true,"given":"Luca","family":"Pesce","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-2923","authenticated-orcid":true,"given":"Marina","family":"Scardigli","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"Division of Physiology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-3904","authenticated-orcid":true,"given":"Giacomo","family":"Mazzamuto","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"National Institute of Optics (INO), National Research Council (CNR), Sesto Fiorentino, Italy."},{"name":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-7828","authenticated-orcid":true,"given":"Vladislav","family":"Gavryusev","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-8905","authenticated-orcid":true,"given":"Filippo Maria","family":"Castelli","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"Bioretics srl, Cesena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-4470","authenticated-orcid":true,"given":"Matteo","family":"Roffilli","sequence":"additional","affiliation":[{"name":"Bioretics srl, Cesena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9215-9104","authenticated-orcid":true,"given":"Ludovico","family":"Silvestri","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"National Institute of Optics (INO), National Research Council (CNR), Sesto Fiorentino, Italy."},{"name":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7473-5558","authenticated-orcid":true,"given":"Jessie","family":"Laffey","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-8442","authenticated-orcid":true,"given":"Sophia","family":"Raia","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-3903","authenticated-orcid":true,"given":"Merina","family":"Varghese","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Wicinski","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-7290","authenticated-orcid":true,"given":"Shuaibin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichun Anderson","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-5845","authenticated-orcid":true,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-4571","authenticated-orcid":true,"given":"Devani","family":"Cordero","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2854-8775","authenticated-orcid":true,"given":"Matthew","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-9107","authenticated-orcid":true,"given":"Jackson","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3178-1300","authenticated-orcid":true,"given":"Kimberly","family":"Nestor","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-408X","authenticated-orcid":true,"given":"Jocelyn","family":"Mora","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-173X","authenticated-orcid":true,"given":"Juan Eugenio","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."},{"name":"Department of Medical Physics and Biomedical Engineering, University College London, London, UK."},{"name":"Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-6698","authenticated-orcid":true,"given":"Erendira","family":"Garcia Pallares","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Evancic","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-6671","authenticated-orcid":true,"given":"Jean C.","family":"Augustinack","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-1923","authenticated-orcid":true,"given":"Morgan","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Imaging Science Program, Washington University McKelvey School of Engineering, St.\u00a0Louis, MO, USA."},{"name":"Department of Radiology, Washington University School of Medicine, St.\u00a0Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-0136","authenticated-orcid":true,"given":"Adrian V.","family":"Dalca","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3940-9861","authenticated-orcid":true,"given":"Matthew P.","family":"Frosch","sequence":"additional","affiliation":[{"name":"C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-7380","authenticated-orcid":true,"given":"Caroline","family":"Magnain","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-9240","authenticated-orcid":true,"given":"Robert","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"van der Kouwe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."},{"name":"Department of Human Biology, University of Cape Town, Cape Town, South Africa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-8412","authenticated-orcid":true,"given":"Shih-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-7711","authenticated-orcid":true,"given":"David A.","family":"Boas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Saverio","family":"Pavone","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI), Italy."},{"name":"National Institute of Optics (INO), National Research Council (CNR), Sesto Fiorentino, Italy."},{"name":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino (FI), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-1115","authenticated-orcid":true,"given":"Bruce","family":"Fischl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Athinoula A.\u00a0Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA."},{"name":"Department of Radiology, Harvard Medical School, Boston, MA, USA."},{"name":"Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA."},{"name":"HST, Massachusetts Institute of Technology, Cambridge, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-1154","authenticated-orcid":true,"given":"Patrick R.","family":"Hof","sequence":"additional","affiliation":[{"name":"Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New\u00a0York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2021.06.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03950-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.569517"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235381"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24080"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.070"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.012"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20488"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14858-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.001838"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.03.004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03390-0"},{"key":"e_1_3_2_15_2","unstructured":"G. Mazzamuto I.\u00a0Costantini V.\u00a0Gavryusev F.\u00a0M.\u00a0Castelli L.\u00a0Pesce M.\u00a0Scardigli F.\u00a0S.\u00a0Pavone M.\u00a0Roffilli L.\u00a0Silvestri P.\u00a0R.\u00a0Hof D.\u00a0A.\u00a0Boas B.\u00a0Fischl L.\u00a0Morgan J.\u00a0Yang S.\u00a0Chang J.\u00a0Laffey C.\u00a0Magnain D.\u00a0Varadarajan H.\u00a0Wang R.\u00a0Frost A.\u00a0v. d. Kouwe A.\u00a0S.\u00a0Player A.\u00a0Atzeni J.\u00a0E.\u00a0I. Gonzalez Y.\u00a0Balbastre M.\u00a0Vera D.\u00a0Cordero K.\u00a0Nestor W.\u00a0Ammon J.\u00a0Nolan J.\u00a0Mora E.\u00a0G.\u00a0Pallares J.\u00a0Augustinack B.\u00a0Diamond M.\u00a0Fogarty E.\u00a0Boyd M.\u00a0Varghese A.\u00a0V.\u00a0Dalca B.\u00a0Edlow M.\u00a0Frosche I.-C.\u00a0A.\u00a0Chen B.\u00a0Wicinski \"https:\/\/dandiarchive.org\/dandiset\/000026\/draft\" U01MH117023 (Version draft) [Data set] DANDI archive (2021)."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-019-0254-8"},{"key":"e_1_3_2_17_2","unstructured":"D. Varadarajan R.\u00a0Frost A.\u00a0van der Kouwe L.\u00a0Morgan B.\u00a0Diamond E.\u00a0Boyd M.\u00a0Fogarty A.\u00a0Stevens B.\u00a0Fischl J.\u00a0R.\u00a0Polimeni Edge-preserving B0 inhomogeneity distortion correction for high-resolution multi-echo ex vivo MRI at 7T. Abstract of International Society for Magnetic Resonance in Medicine 664 (2020)."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.016"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1109\/42.811268"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.7.4.045005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1854"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","unstructured":"L. Pesce L.\u00a0Annunziatina G.\u00a0Vladislav M.\u00a0Giacomo S.\u00a0Giuseppe S.\u00a0Marina R.\u00a0Matteo S.\u00a0Ludovico C.\u00a0Irene P.\u00a0Francesco Saverio Fast volumetric mapping of human brain slices. Proc. SPIE 11360 (2020).","DOI":"10.1101\/2020.10.27.357186"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(91)90096-U"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960603)369:3<472::AID-CNE11>3.0.CO;2-K"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24976"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.10.005251"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.060"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.036"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3444"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.10.004"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-0976-6"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00942-9"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.025"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.415555"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu469"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01208-1"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12107"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30533-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10760"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.010"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0355-3"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav8130"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01530-z"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.025"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20314"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.7.071203"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1364\/OPEX.12.002404"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","unstructured":"I. Arganda-Carreras C.\u00a0O.\u00a0S. Sorzano R.\u00a0Marabini J.\u00a0M.\u00a0Carazo C.\u00a0Ortiz-de-Solorzano J.\u00a0Kybic Consistent and elastic registration of histological sections using vector-spline regularization. Conference paper on Computer Vision Approaches to Medical Image Analysis . 4241 (2006).","DOI":"10.1007\/11889762_8"},{"key":"e_1_3_2_49_2","first-page":"3645","article-title":"Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography","volume":"69","author":"Yang J.","year":"2022","unstructured":"J.\u00a0Yang, S.\u00a0Chang, I. A.\u00a0Chen, S.\u00a0Kura, G. A.\u00a0Rosen, N. A.\u00a0Saltiel, B. R.\u00a0Huber, D.\u00a0Varadarajan, Y.\u00a0Balbastre, C.\u00a0Magnain, S.-C.\u00a0Chen, B.\u00a0Fischl, A. C.\u00a0McKee, D. A.\u00a0Boas, H.\u00a0Wang, Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography. I.E.E.E. Trans. Biomed. Eng. 69, 3645\u20133656 (2022).","journal-title":"I.E.E.E. Trans. Biomed. Eng."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep09808"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2021.09.001"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86092-7"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2021.752234"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1364\/AOP.10.000111"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.NPh.2.4.041404"},{"key":"e_1_3_2_56_2","first-page":"924","article-title":"A log-Euclidean framework for statistics on diffeomorphisms","volume":"9","author":"Arsigny V.","year":"2006","unstructured":"V.\u00a0Arsigny, O.\u00a0Commowick, X.\u00a0Pennec, N.\u00a0Ayache, A log-Euclidean framework for statistics on diffeomorphisms. Med. Image Comput. Comput. Assist. Interv. 9, 924\u2013931 (2006).","journal-title":"Med. Image Comput. Comput. Assist. Interv."},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","unstructured":"P. Cachier X.\u00a0Pennec 3D non-rigid registration by gradient descent on a Gaussian-windowed similarity measure using convolutions. Proceedings IEEE Workshop on Mathematical Methods in Biomedical Image Analysis . MMBIA-2000 (Cat. No.PR00737) 182\u2013189 (2000).","DOI":"10.1109\/MMBIA.2000.852376"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.4086\/toc.2012.v008a019"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adg3844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T19:05:18Z","timestamp":1730315118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adg3844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":57,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2023,10,13]]}},"alternative-id":["10.1126\/sciadv.adg3844"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adg3844","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"2022-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadg3844"}}