{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:19:32Z","timestamp":1789661972384,"version":"4.0.1"},"reference-count":36,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"25","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,6,23]]},"abstract":"<jats:p>\n                    The association between rewarding and drug-related memory is a leading factor for the formation of addiction, yet the neural circuits underlying the association remain unclear. Here, we showed that the interstitial nucleus of the posterior limb of the anterior commissure (IPAC) integrated rewarding and environmental memory information by two different receiving projections from ventral tegmental area (VTA) and nucleus accumbens shell region (NAcSh) to mediate the acquisition of morphine conditioned place preference (CPP). A projection from the VTA GABAergic neurons (VTA\n                    <jats:sup>GABA<\/jats:sup>\n                    ) to the IPAC lateral region GABAergic neurons (IPACL\n                    <jats:sup>GABA<\/jats:sup>\n                    ) mediated the effect of morphine rewarding, whereas the pathway from NAcSh dopamine receptor 1\u2013expressing neurons (NAcSh\n                    <jats:sup>D1<\/jats:sup>\n                    ) to the IPAC medial region GABAergic neurons (IPACM\n                    <jats:sup>GABA<\/jats:sup>\n                    ) was involved in the acquisition of environmental memory. These findings demonstrated that the distinct IPAC circuits VTA\n                    <jats:sup>GABA<\/jats:sup>\n                    <jats:bold>\u2192<\/jats:bold>\n                    IPACL\n                    <jats:sup>GABA<\/jats:sup>\n                    and NAcSh\n                    <jats:sup>D1R<\/jats:sup>\n                    <jats:bold>\u2192<\/jats:bold>\n                    IPACM\n                    <jats:sup>GABA<\/jats:sup>\n                    were attributable to the rewarding and environmental memory during the acquisition of morphine CPP, respectively, and provided the circuit-based potential targets for preventing and treating opioid addiction.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adg5849","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T14:10:27Z","timestamp":1687529427000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":15,"title":["IPAC integrates rewarding and environmental memory during the acquisition of morphine CPP"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-2895","authenticated-orcid":true,"given":"Huan-Min","family":"Liu","sequence":"first","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7854-3134","authenticated-orcid":true,"given":"Ming-Lu","family":"Liao","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-9588","authenticated-orcid":true,"given":"Guan-Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-1859","authenticated-orcid":true,"given":"Lai-Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-3233","authenticated-orcid":true,"given":"Dian","family":"Lian","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3061-4068","authenticated-orcid":true,"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3551-7090","authenticated-orcid":true,"given":"Xin-Tian","family":"Chi","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Ran","family":"Lv","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2686-7571","authenticated-orcid":true,"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine, Guangzhou First People\u2019s Hospital, Guangzhou 510000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-2340","authenticated-orcid":true,"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-9814","authenticated-orcid":true,"given":"Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-1951","authenticated-orcid":true,"given":"Jia-You","family":"Wei","sequence":"additional","affiliation":[{"name":"Neuroscience Program, Zhongshan School of Medicine, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-9803","authenticated-orcid":true,"given":"Xia","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-2160","authenticated-orcid":true,"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou 510080, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-6228","authenticated-orcid":true,"given":"Xue-Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Institute of Mental Psychology, School of Health Management, The Affiliated Brain Hospital (Guangzhou Huiai Hospital), Guangzhou Medical University, Guangzhou 510370, 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