{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:38:17Z","timestamp":1791981497157,"version":"4.4.0"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"20","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,5,19]]},"abstract":"<jats:p>\n                    Regulatory T (T\n                    <jats:sub>reg<\/jats:sub>\n                    ) cells underlie multiple autoimmune disorders and potentialize an anti-inflammation treatment with adoptive cell therapy. However, systemic delivery of cellular therapeutics often lacks tissue targeting and accumulation for localized autoimmune diseases. Besides, the instability and plasticity of T\n                    <jats:sub>reg<\/jats:sub>\n                    cells also induce phenotype transition and functional loss, impeding clinical translation. Here, we developed a perforated microneedle (PMN) with favorable mechanical performance and a spacious encapsulation cavity to support cell survival, as well as tunable channels to facilitate cell migration for local T\n                    <jats:sub>reg<\/jats:sub>\n                    therapy of psoriasis. In addition, the enzyme-degradable microneedle matrix could release fatty acid in the hyperinflammatory area of psoriasis, enhancing the T\n                    <jats:sub>reg<\/jats:sub>\n                    suppressive functions via the fatty acid oxidation (FAO)\u2013mediated metabolic intervention. T\n                    <jats:sub>reg<\/jats:sub>\n                    cells administered through PMN substantially ameliorated psoriasis syndrome with the assistance of fatty acid\u2013mediated metabolic intervention in a psoriasis mouse model. This tailorable PMN could offer a transformative platform for local cell therapy to treat a variety of diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adg6007","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T13:57:16Z","timestamp":1684331836000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":90,"title":["Adoptive T\n                    <sub>reg<\/sub>\n                    therapy with metabolic intervention via perforated microneedles ameliorates psoriasis syndrome"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-4659","authenticated-orcid":true,"given":"Wentao","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-9731","authenticated-orcid":true,"given":"Yingxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."},{"name":"Institute of Advanced Magnetic Materials and International Research Center for EM Metamaterials, College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-6367","authenticated-orcid":true,"given":"Shenqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-0082","authenticated-orcid":true,"given":"Ziyan","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9331-2326","authenticated-orcid":true,"given":"Tao","family":"Sheng","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-8918","authenticated-orcid":true,"given":"Xinmin","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Burns and Wound Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-6671","authenticated-orcid":true,"given":"Jicheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."},{"name":"Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China."},{"name":"Jinhua Institute of Zhejiang University, Jinhua 321299, China."},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 311121, China."},{"name":"National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-7722","authenticated-orcid":true,"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China."},{"name":"Department of Burns and Wound Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China."},{"name":"National Key Laboratory of Advanced Drug 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