{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:52:42Z","timestamp":1778899962127,"version":"3.51.4"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"46","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,11,17]]},"abstract":"<jats:p>\n            Thymic epithelial cells (TEC) control T cell development and play essential roles in establishing self-tolerance. By using\n            <jats:italic>Foxn1-Cre<\/jats:italic>\n            \u2013driven ablation of\n            <jats:italic>Klf6<\/jats:italic>\n            gene in TEC, we identified\n            <jats:italic>Klf6<\/jats:italic>\n            as a critical factor in TEC development.\n            <jats:italic>Klf6<\/jats:italic>\n            deficiency resulted in a hypoplastic thymus\u2014evident from fetal stages into adulthood\u2014in which a dramatic increase in the frequency of apoptotic TEC was observed. Among cortical TEC (cTEC), a previously unreported cTEC population expressing the transcription factor Sox10 was relatively expanded. Within medullary TEC (mTEC), mTEC I and Tuft-like mTEC IV were disproportionately decreased.\n            <jats:italic>Klf6<\/jats:italic>\n            deficiency altered chromatin accessibility and affected TEC chromatin configuration. Consistent with these defects, na\u00efve conventional T cells and invariant natural killer T cells were reduced in the spleen. Late stages of T cell receptor\u2013dependent selection of thymocytes were affected, and mice exhibited autoimmunity. Thus, Klf6 has a prosurvival role and affects the development of specific TEC subsets contributing to thymic function.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adg8126","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:58:28Z","timestamp":1700074708000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0842-1747","authenticated-orcid":true,"given":"Justin","family":"Malin","sequence":"first","affiliation":[{"name":"Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 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