{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:03:32Z","timestamp":1791864212629,"version":"4.3.4"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"45","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,11,10]]},"abstract":"<jats:p>\n            Circulating senescent CD8\n            <jats:sup>+<\/jats:sup>\n            T (T\n            <jats:sub>8<\/jats:sub>\n            sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in patients with advanced non\u2013small cell lung cancer (aNSCLC). We aimed to better characterize T\n            <jats:sub>8<\/jats:sub>\n            sen and to determine which factors were associated with their accumulation in patients with aNSCLC. Circulating T\n            <jats:sub>8<\/jats:sub>\n            sen cells were characterized by a higher expression of SA-\u03b2gal and the transcription factor T-bet, confirming their senescent status. Using whole virome profiling, cytomegalovirus (CMV) was the only virus associated with T\n            <jats:sub>8<\/jats:sub>\n            sen. CMV was necessary but not sufficient to explain high accumulation of T\n            <jats:sub>8<\/jats:sub>\n            sen (T\n            <jats:sub>8<\/jats:sub>\n            sen\n            <jats:sup>high<\/jats:sup>\n            status). In CMV\n            <jats:sup>+<\/jats:sup>\n            patients, the proportion of T\n            <jats:sub>8<\/jats:sub>\n            sen cells increased with cancer progression. Last, CMV-induced T\n            <jats:sub>8<\/jats:sub>\n            sen\n            <jats:sup>high<\/jats:sup>\n            phenotype but not CMV seropositivity itself was associated with worse progression-free and overall survival in patients treated with anti\u2013PD-(L)1 therapy but not with chemotherapy. Overall, CMV is the unique viral driver of T\n            <jats:sub>8<\/jats:sub>\n            sen-driven resistance to anti\u2013PD-(L)1 antibodies in patients with aNSCLC.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adh0708","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T18:58:31Z","timestamp":1699469911000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":35,"title":["Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8\n            <sup>+<\/sup>\n            T cells in patients with advanced NSCLC"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-7720","authenticated-orcid":true,"given":"Marie","family":"Naigeon","sequence":"first","affiliation":[{"name":"Laboratoire d'Immunomonitoring en Oncologie, INSERM US23, CNRS UMS 3655, Gustave Roussy, Villejuif, France."},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France."},{"name":"Facult\u00e9 de Pharmacie, Universit\u00e9 Paris-Saclay, Orsay, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-2342","authenticated-orcid":true,"given":"Matthieu","family":"Roulleaux Dugage","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunomonitoring en Oncologie, INSERM US23, CNRS UMS 3655, Gustave Roussy, Villejuif, France."},{"name":"Service d\u2019Oncologie M\u00e9dicale, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France."},{"name":"D\u00e9partement d\u2019Innovation Th\u00e9rapeutique et d\u2019Essais Pr\u00e9coces (DITEP), Gustave Roussy, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-064X","authenticated-orcid":true,"given":"Fran\u00e7ois-Xavier","family":"Danlos","sequence":"additional","affiliation":[{"name":"Facult\u00e9 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