{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:32:03Z","timestamp":1788093123781,"version":"build-2803163510"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"44","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:p>Choroidal melanoma, a common intraocular malignant tumor, relies on local radiotherapy and enucleation for treatment. However, cancer recurrence and visual impairment remain important challenges. Here, a therapeutic artificial vitreous body (AVB) hydrogel based on tetra-armed poly(ethylene glycol) was developed to control the recurrence of choroidal melanoma and preserve vision after vitrectomy. AVB loaded with melphalan (Mel) and anti\u2013programmed cell death ligand-1 (\u03b1PDL1), was injected after surgical resection in the choroidal melanoma mouse model. Afterwards, the sequentially released Mel and \u03b1PDL1 from AVB could achieve a synergistic antitumor effect to inhibit tumor recurrence. AVB with similar physical properties to native vitreous body could maintain the normal structure and visual function of eye after vitrectomy, which has been evidenced by standard examinations of ophthalmology in the mouse model. Thus, the immunotherapeutic AVB may be a promising candidate as an infill biomaterial to assist surgical treatment of intraocular malignant tumors.<\/jats:p>","DOI":"10.1126\/sciadv.adh1582","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:58:43Z","timestamp":1698861523000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["An immunotherapeutic artificial vitreous body hydrogel to control choroidal melanoma and preserve vision after vitrectomy"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2703-5516","authenticated-orcid":true,"given":"Muchao","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials and Devices, Soochow University, 199 Ren\u2019ai Road, Suzhou, Jiangsu 215123, P.R. 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