{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:57:37Z","timestamp":1792645057569,"version":"4.5.0"},"reference-count":38,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"35","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    Biological systems are inherently noisy; however, they produce highly stereotyped tissue morphology.\n                    <jats:italic>Drosophila<\/jats:italic>\n                    pupal wings show a highly stereotypic folding through uniform expansion and subsequent buckling of wing epithelium within a surrounding cuticle sac. The folding pattern produced by buckling is generally stochastic; it is thus unclear how buckling leads to stereotypic tissue folding of the wings. We found that the extracellular matrix (ECM) protein, Dumpy, guides the position and direction of buckling-induced folds. Dumpy anchors the wing epithelium to the overlying cuticle at specific tissue positions. Tissue-wide alterations of Dumpy deposition and degradation yielded different buckling patterns. In summary, we propose that spatiotemporal ECM remodeling shapes stereotyped tissue folding through dynamic interactions between the epithelium and its external structures.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adh2154","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:58:26Z","timestamp":1693576706000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["Spatiotemporal remodeling of extracellular matrix orients epithelial sheet folding"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6055-3844","authenticated-orcid":true,"given":"Alice","family":"Tsuboi","sequence":"first","affiliation":[{"name":"Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-7990","authenticated-orcid":true,"given":"Koichi","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Osaka University, Toyonaka, Osaka 560-0043, Japan."},{"name":"Program of Mathematical and Life Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-1141","authenticated-orcid":true,"given":"Takefumi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan."},{"name":"The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Sakyo-ku, Kyoto 606-8501, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.4032128"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00318-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982977"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.2.509"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00298"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2016.10.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2222"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2180"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.06.019"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07090"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.01.010"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55965"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.111310"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.111054"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.11.4937"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.06.006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007882"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.184564"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711408114"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1591"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.042"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.01.021"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.12.020"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80403-7"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.172577"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.3.785"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200905110"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.05.029"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14838"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11792"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611511104"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134426"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","unstructured":"B. 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