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Here, we report that GABAergic redox signaling cell nonautonomously activates many stress response pathways in\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            and enhances vulnerability to proteostasis disease in the absence of oxidative stress. Cell nonautonomous redox activation of the mitochondrial unfolded protein response (mitoUPR) proteostasis network requires UNC-49, a GABA\n            <jats:sub>A<\/jats:sub>\n            receptor that we show is activated by hydrogen peroxide. MitoUPR induction by a spinocerebellar ataxia type 3 (SCA3)\n            <jats:italic>C. elegans<\/jats:italic>\n            neurodegenerative disease model was similarly dependent on UNC-49 in\n            <jats:italic>C. elegans<\/jats:italic>\n            . These results demonstrate a multi-tissue paradigm for redox signaling in the GABAergic system that is transduced via a GABA\n            <jats:sub>A<\/jats:sub>\n            receptor to function in cell nonautonomous regulation of health, proteostasis, and disease.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adh2584","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:58:43Z","timestamp":1698861523000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["UNC-49 is a redox-sensitive GABA\n            <sub>A<\/sub>\n            receptor that regulates the mitochondrial unfolded protein response cell nonautonomously"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-1268","authenticated-orcid":true,"given":"Franziska","family":"Pohl","sequence":"first","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, 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