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A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. Single-dose intranasal vaccination up to 3 days before challenge prevented clinical signs and reduced virus levels in hamsters and immunocompromised mice; decreases were seen in tissues and mucosal secretions, critically decreasing potential for virus transmission. This virus replicon particle system provides a vital tool to the field and demonstrates utility as a highly efficacious and safe vaccine candidate that can be administered parenterally or mucosally to protect against lethal Nipah disease.<\/jats:p>","DOI":"10.1126\/sciadv.adh4057","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T13:58:23Z","timestamp":1691157503000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":36,"title":["Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-8521","authenticated-orcid":true,"given":"Stephen R.","family":"Welch","sequence":"first","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-0513","authenticated-orcid":true,"given":"Jessica R.","family":"Spengler","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-8035","authenticated-orcid":true,"given":"Sarah C.","family":"Genzer","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-2224","authenticated-orcid":true,"given":"JoAnn D.","family":"Coleman-McCray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-0254","authenticated-orcid":true,"given":"Jessica R.","family":"Harmon","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa E.","family":"Sorvillo","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-3087","authenticated-orcid":true,"given":"Florine E.\u00a0M.","family":"Scholte","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-7458","authenticated-orcid":true,"given":"Sergio E.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9818-4463","authenticated-orcid":true,"given":"T. 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