{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:22:19Z","timestamp":1779348139834,"version":"3.51.4"},"reference-count":57,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,1,19]]},"abstract":"<jats:p>\n                    Acute thymic atrophy occurs following type 1 inflammatory conditions such as viral infection and sepsis, resulting in cell death and disruption of T cell development. However, the impact type 1 immunity has on thymic-resident innate lymphoid cells (ILCs) remains unclear. Single-cell RNA sequencing revealed neonatal thymic\u2013resident type 1 ILCs (ILC1s) as a unique and immature subset compared to ILC1s in other primary lymphoid organs. Culturing murine neonatal thymic lobes with the type 1 cytokines interleukin-12 (IL-12) and IL-18 resulted in a rapid expansion and thymic egress of KLRG1\n                    <jats:sup>+<\/jats:sup>\n                    CXCR6\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic ILC1s. Live imaging showed the subcapsular thymic localization and exit of ILC1s following IL-12 + IL-18 stimulation. Similarly, murine cytomegalovirus infection in neonates resulted in thymic atrophy and subcapsular localization of thymic-resident ILC1s. Neonatal thymic grafting revealed that type 1 inflammation enhances the homing of cytokine-producing thymus-derived ILC1s to the liver and peritoneal cavity. Together, we show that type 1 immunity promotes the expansion and peripheral homing of thymic-derived ILC1s.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adh5520","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T13:59:36Z","timestamp":1705499976000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":10,"title":["Type 1 immunity enables neonatal thymic ILC1 production"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-4152","authenticated-orcid":true,"given":"Peter","family":"Tougaard","sequence":"first","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-5200","authenticated-orcid":true,"given":"Mario R.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-9884","authenticated-orcid":true,"given":"Wolf","family":"Steels","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-3031","authenticated-orcid":true,"given":"Jelle","family":"Huysentruyt","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3573-1463","authenticated-orcid":true,"given":"Bruno","family":"Verstraeten","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-0086","authenticated-orcid":true,"given":"Jessica","family":"Vetters","sequence":"additional","affiliation":[{"name":"Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Divert","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2748-3033","authenticated-orcid":true,"given":"Amanda","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."},{"name":"VIB BioImaging Core, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-7555","authenticated-orcid":true,"given":"Ria","family":"Roelandt","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-4203","authenticated-orcid":true,"given":"Nozomi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Cell death and Inflammation Unit, VIB-UGent Center for Inflammation Research, Ghent, Belgium."},{"name":"Department of Biomedical Molecular Biology, Ghent University, Ghent, 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