{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T20:09:00Z","timestamp":1785614940770,"version":"3.56.0"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,9,22]]},"abstract":"<jats:p>\n            Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The\n            <jats:italic>rs2204985<\/jats:italic>\n            genetic polymorphism within the\n            <jats:italic>TCRA-TCRD<\/jats:italic>\n            locus, which affects thymic output in healthy individuals, was found here to modify SARS-CoV-2\u2013specific immunity and disease severity in COVID-19 patients with severe pneumonia. Forty patients with severe COVID-19 pneumonia were investigated. The GG genotype at the\n            <jats:italic>rs2204985<\/jats:italic>\n            locus was associated, independently of age and sex, with stronger and long-lasting anti\u2013SARS-CoV-2 helper and cytotoxic T cell responses 6 months after recovery. The GG genotype was also associated with less severe lung involvement, higher thymic production, and higher counts of blood na\u00efve T lymphocytes, including recent thymic emigrants, and a larger population of activated stem cell memory CD4\n            <jats:sup>+<\/jats:sup>\n            T cells. Overall, GG patients developed a more robust and sustained immunity to SARS-CoV-2. Polymorphism at\n            <jats:italic>rs2204985<\/jats:italic>\n            locus should be considered as an additional predictive marker of anti\u2013SARS-CoV-2 immune response.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adh7969","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:58:33Z","timestamp":1695405513000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":13,"title":["Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-8053","authenticated-orcid":true,"given":"H\u00e9l\u00e8ne M.","family":"Roux","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-7290","authenticated-orcid":true,"given":"Amira","family":"Marouf","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier priv\u00e9 Ambroise Par\u00e9-Hartmann, D\u00e9partement Recherche Innovation, 92200, Neuilly-Sur-Seine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-6136","authenticated-orcid":true,"given":"Jacques","family":"Dutrieux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Charmeteau-De Muylder","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Figueiredo-Morgado","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-2990","authenticated-orcid":true,"given":"V\u00e9ronique","family":"Avettand-Fenoel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Facult\u00e9 de m\u00e9decine, Institut Cochin-CNRS 8104\/INSERM U1016 AP-HP, Service de Virologie, H\u00f4pital Cochin, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3303-1128","authenticated-orcid":true,"given":"Pelagia","family":"Cuvelier","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier priv\u00e9 Ambroise Par\u00e9-Hartmann, D\u00e9partement Recherche Innovation, 92200, Neuilly-Sur-Seine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Naudin","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier priv\u00e9 Ambroise Par\u00e9-Hartmann, D\u00e9partement Recherche Innovation, 92200, Neuilly-Sur-Seine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier priv\u00e9 Ambroise Par\u00e9-Hartmann, D\u00e9partement Recherche Innovation, 92200, Neuilly-Sur-Seine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Geri","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier priv\u00e9 Ambroise Par\u00e9-Hartmann, D\u00e9partement Recherche Innovation, 92200, Neuilly-Sur-Seine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-2509","authenticated-orcid":true,"given":"Anne","family":"Cou\u00ebdel-Courteille","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Squara","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier priv\u00e9 Ambroise Par\u00e9-Hartmann, D\u00e9partement Recherche Innovation, 92200, Neuilly-Sur-Seine, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-9973","authenticated-orcid":true,"given":"Stefano","family":"Marullo","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1146-660X","authenticated-orcid":true,"given":"R\u00e9mi","family":"Cheynier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin, F-75014 Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4570"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"D. 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