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In this study, we demonstrate a \u201cpleiotropic gas transmitter\u201d strategy based on endogenous reactive oxygen species (ROS), which trigger the on-demand H\n                    <jats:sub>2<\/jats:sub>\n                    S release at the defect area for transected peripheral nerve injury (PNI) repair through concurrent neuroregeneration and neuroprotection processing. This H\n                    <jats:sub>2<\/jats:sub>\n                    S delivery system consists of an H\n                    <jats:sub>2<\/jats:sub>\n                    S donor (peroxyTCM) encapsulated in a ROS-responsive polymer (mPEG-PMet) and loaded into a temperature-sensitive poly (amino acid) hydrogel (mPEG-PA-PP). This multi-effect combination strategy greatly promotes the regeneration of PNI, attributed to the physiological effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S. These effects include the inhibition of inflammation and oxidative stress, protection of nerve cells, promotion of angiogenesis, and the restoration of normal mitochondrial function. The adaptive release of pleiotropic messengers to modulate the tissue regeneration microenvironment offers promising peripheral nerve repair and tissue engineering opportunities.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adi1078","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T13:58:40Z","timestamp":1703080720000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":100,"title":["An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-0895","authenticated-orcid":true,"given":"Xianzhen","family":"Dong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 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