{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:48:33Z","timestamp":1787161713836,"version":"build-2736575974"},"reference-count":82,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"30","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2025,7,25]]},"abstract":"<jats:p>\n                    Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced pluripotent stem cells (iPSCs). The iPSC-MCs closely resemble human primary MCs at cellular, transcriptional, and functional levels. Using this method, a breast cancer model was generated using patient-derived iPSCs harboring germline\n                    <jats:italic>BRCA1<\/jats:italic>\n                    mutation. The patient iPSC-MCs recapitulated the transcriptome, clinical genomic alteration, and tumorigenic ability of breast cancer cells. We also identified S100P as an oncogene downstream of mutated\n                    <jats:italic>BRCA1<\/jats:italic>\n                    that promotes cancer cell stemness and tumorigenesis. Our study establishes a promising system of breast cancer for studying the mechanism of tumorigenesis and identifying potential therapeutic targets.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adi2370","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T17:58:38Z","timestamp":1753466318000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by\n                    <i>BRCA1<\/i>\n                    mutation"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7861-0626","authenticated-orcid":true,"given":"Jingxin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China."},{"name":"Cancer Institute, Xuzhou Medical University, 221002, Jiangsu, China."},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Department of Gynecology and Obstetrics, West China Second Hospital, West China Biomedical Big Data Center, West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China."},{"name":"School of Basic Medical Sciences, Guangdong Medical University, Advanced Medical Technology Center, The First Affiliated Hospital, Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China."},{"name":"Vaccine Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510630, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9884-8698","authenticated-orcid":true,"given":"Cai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China."},{"name":"Cancer Institute, Xuzhou Medical University, 221002, Jiangsu, China."},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Department of Gynecology and Obstetrics, West China Second Hospital, West China Biomedical Big Data Center, West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China."},{"name":"School of Basic Medical Sciences, Guangdong Medical University, Advanced Medical Technology Center, The First Affiliated Hospital, Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China."},{"name":"Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, 18 Zetian Road, Futian District, Shenzhen, 518040, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3413-5005","authenticated-orcid":true,"given":"Jiahao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China."},{"name":"Cancer Institute, Xuzhou Medical University, 221002, Jiangsu, China."},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Department of Gynecology and Obstetrics, West China Second Hospital, West China Biomedical Big Data Center, West China Hospital\/West China School of Medicine, Sichuan University, Chengdu 610041, China."},{"name":"School of Basic Medical Sciences, Guangdong Medical University, Advanced Medical Technology Center, The First Affiliated Hospital, Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China."},{"name":"Vaccine Research Institute, The Third Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, 510630, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-436X","authenticated-orcid":true,"given":"Pengguihang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China."},{"name":"Cancer Institute, Xuzhou Medical University, 221002, Jiangsu, China."},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, 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