{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:13:59Z","timestamp":1791598439530,"version":"4.3.4"},"reference-count":62,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,8,25]]},"abstract":"<jats:p>\n                    Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-reperfusion injury in the heart and several degenerative diseases, including muscular dystrophy (MD). MD is a family of genetic disorders characterized by progressive muscle necrosis and premature death. It has been proposed that the MPTP has two molecular components, the adenine nucleotide translocase (ANT) family of proteins and an unknown component that requires the chaperone cyclophilin D (CypD) to activate. This model was examined in vivo by deleting the gene encoding ANT1 (\n                    <jats:italic>Slc25a4<\/jats:italic>\n                    ) or CypD (\n                    <jats:italic>Ppif<\/jats:italic>\n                    ) in a \u03b4-sarcoglycan (\n                    <jats:italic>Sgcd<\/jats:italic>\n                    ) gene\u2013deleted mouse model of MD, revealing that dystrophic mice lacking\n                    <jats:italic>Slc25a4<\/jats:italic>\n                    were partially protected from cell death and MD pathology. Dystrophic mice lacking both\n                    <jats:italic>Slc25a4<\/jats:italic>\n                    and\n                    <jats:italic>Ppif<\/jats:italic>\n                    together were almost completely protected from necrotic cell death and MD disease. This study provides direct evidence that ANT1 and CypD are required MPTP components governing in vivo cell death, suggesting a previously unrecognized therapeutic approach in MD and other necrotic diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adi2767","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:58:21Z","timestamp":1692971901000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":49,"title":["ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-5489","authenticated-orcid":true,"given":"Michael J.","family":"Bround","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Cincinnati Children's Hospital and the University of Cincinnati, Cincinnati, OH, 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