{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:04:41Z","timestamp":1793840681508,"version":"4.6.1"},"reference-count":80,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"44","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,11,3]]},"abstract":"<jats:p>\n                    Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus (GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we report the association of placental inflammation (tumor necrosis factor\u2013\u03b1) and abnormal maternal glucose metabolism in patients with GDM, and a high fermentable dietary fiber (HFDF;\n                    <jats:italic>konjac<\/jats:italic>\n                    ) could reduce GDM development through gut flora\u2013short-chain fatty acid\u2013placental inflammation axis in GDM mouse model. Mechanistically, HFDF increases abundances of\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    and butyrate, reduces placental-derived inflammation by enhancing gut barrier and inhibiting the transfer of bacterial-derived lipopolysaccharide, and ultimately resists high-fat diet\u2013induced insulin resistance.\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    and butyrate have similar anti-GDM and anti\u2013placental inflammation effects, and they can ameliorate placental function and pregnancy outcome effects probably by dampening placental immune dysfunction. These findings demonstrate the involvement of important placental inflammation\u2013related mechanisms in the progression of GDM and the great potential of HFDFs to reduce susceptibility to GDM through gut-flora-placenta axis.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adi7337","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T13:59:10Z","timestamp":1699019950000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":187,"title":["<i>Lachnospiraceae<\/i>\n                    -derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-9838","authenticated-orcid":true,"given":"Shuangbo","family":"Huang","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering 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