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Nanoplastics can internalize in neurons through clathrin-dependent endocytosis, causing a mild lysosomal impairment that slows the degradation of aggregated \u03b1-synuclein. In mice, nanoplastics combine with \u03b1-synuclein fibrils to exacerbate the spread of \u03b1-synuclein pathology across interconnected vulnerable brain regions, including the strong induction of \u03b1-synuclein inclusions in dopaminergic neurons in the substantia nigra. These results highlight a potential link for further exploration between nanoplastic pollution and \u03b1-synuclein aggregation associated with Parkinson\u2019s disease and related dementias.<\/jats:p>","DOI":"10.1126\/sciadv.adi8716","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T14:01:01Z","timestamp":1700229661000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":261,"title":["Anionic nanoplastic contaminants promote Parkinson\u2019s disease\u2013associated \u03b1-synuclein aggregation"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2959-5189","authenticated-orcid":true,"given":"Zhiyong","family":"Liu","sequence":"first","affiliation":[{"name":"Duke Center for Neurodegeneration and Neurotheraputics, Duke University, Durham, NC, 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