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We hereby demonstrate a fully biocompatible wireless microelectronics with a self-assembled design that can be rolled into a lightweight microtubular pacemaker for intravascular implantation and pacing. The radio frequency was used to transfer energy to the microtubular pacemaker for electrical stimulation. We show that this pacemaker provides effective pacing to restore cardiac contraction from a nonbeating heart and have the capacity to perform overdrive pacing to augment blood circulation in an anesthetized pig model. Thus, this microtubular pacemaker paves the way for the minimally invasive implantation of leadless and battery-free microelectronics.<\/jats:p>","DOI":"10.1126\/sciadv.adj0540","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T13:58:36Z","timestamp":1697637516000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":78,"title":["A self-assembled implantable microtubular pacemaker for wireless cardiac electrotherapy"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-0550","authenticated-orcid":true,"given":"Shaolei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA."},{"name":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, 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