{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:58:46Z","timestamp":1790780326882,"version":"4.1.0"},"reference-count":59,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"1","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,1,5]]},"abstract":"<jats:p>\n                    The dual role of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in influenza control and lung pathology is increasingly appreciated. To explore whether protective and pathological functions can be linked to specific subsets, we dissected CD8\n                    <jats:sup>+<\/jats:sup>\n                    T responses in influenza-infected murine lungs. Our single-cell RNA-sequencing (scRNA-seq) analysis revealed notable diversity in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T subpopulations during peak viral load and infection-resolved state. While enrichment of a Cxcr3\n                    <jats:sup>hi<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T effector subset was associated with a more robust cytotoxic response, both CD8\n                    <jats:sup>+<\/jats:sup>\n                    T effector and central memory exhibited equally potent effector potential. The scRNA-seq analysis identified unique regulons regulating the cytotoxic response in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. The late-stage CD8\n                    <jats:sup>+<\/jats:sup>\n                    T blockade in influenza-cleared lungs or continuous CXCR3 blockade mitigated lung injury without affecting viral clearance. Furthermore, adoptive transfer of wild-type CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells exacerbated influenza lung pathology in Cxcr3\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Collectively, our data imply that CXCR3 interception could have a therapeutic effect in preventing influenza-linked lung injury.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adj1120","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:58:17Z","timestamp":1704290297000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":23,"title":["The chemokine receptor CXCR3 promotes CD8\n                    <sup>+<\/sup>\n                    T cell\u2013dependent lung pathology during influenza pathogenesis"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4651-781X","authenticated-orcid":true,"given":"Kai","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-503X","authenticated-orcid":true,"given":"Dan J. 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USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-2149","authenticated-orcid":true,"given":"Junguk","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-4511","authenticated-orcid":true,"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA."},{"name":"Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-0843","authenticated-orcid":true,"given":"Michal A.","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Research 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