{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:17:01Z","timestamp":1784157421634,"version":"3.55.0"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"36","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,9,8]]},"abstract":"<jats:p>\n            Kyasanur Forest disease virus (KFDV) is an endemic arbovirus in western India mainly transmitted by hard ticks of the genus\n            <jats:italic>Haemaphysalis<\/jats:italic>\n            . KFDV causes Kyasanur Forest disease (KFD), a syndrome including fever, gastrointestinal symptoms, and hemorrhages. There are no approved treatments, and the efficacy of the only vaccine licensed in India has recently been questioned. Here, we studied the protective efficacy of a vesicular stomatitis virus (VSV)\u2013based vaccine expressing the KFDV precursor membrane and envelope proteins (VSV-KFDV) in pigtailed macaques. VSV-KFDV vaccination was found to be safe and elicited strong humoral and cellular immune responses. A single-dose vaccination reduced KFDV loads and pathology and protected macaques from KFD-like disease. Furthermore, VSV-KFDV elicited cross-reactive neutralizing immune responses to Alkhurma hemorrhagic fever virus, a KFDV variant found in Saudi Arabia.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adj1428","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:59:12Z","timestamp":1694023152000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":19,"title":["Single-dose VSV-based vaccine protects against Kyasanur Forest disease in nonhuman primates"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7254-7871","authenticated-orcid":true,"given":"Bharti","family":"Bhatia","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-5855","authenticated-orcid":true,"given":"Tsing-Lee","family":"Tang-Huau","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1363-1077","authenticated-orcid":true,"given":"Friederike","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-1818","authenticated-orcid":true,"given":"Patrick W.","family":"Hanley","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-7423","authenticated-orcid":true,"given":"Rebecca","family":"Rosenke","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-8821","authenticated-orcid":true,"given":"Carl","family":"Shaia","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-9587","authenticated-orcid":true,"given":"Andrea","family":"Marzi","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-8227","authenticated-orcid":true,"given":"Heinz","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"248","article-title":"Russian spring-summer virus in India: Kyasanur Forest disease","volume":"1","author":"Work T. H.","year":"1958","unstructured":"T. H.\u00a0Work, Russian spring-summer virus in India: Kyasanur Forest disease. Prog. Med. Virol. 1, 248\u2013279 (1958).","journal-title":"Prog. Med. Virol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00149"},{"key":"e_1_3_2_4_2","unstructured":"Kyasanur Forest Disease. Centers For Disease Control and Prevention (2013). https:\/\/cdc.gov\/vhf\/kyasanur\/index.html."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.10.005"},{"key":"e_1_3_2_6_2","unstructured":"Select Agents and Toxins List; Centers for Disease Control and Prevention (2023); https:\/\/www.selectagents.gov\/sat\/list.htm"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8091406"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.345.6193.130"},{"key":"e_1_3_2_9_2","first-page":"341","article-title":"Summary of preliminary report of investigations of the Virus Research Centre on an epidemic disease affecting forest villagers and wild monkeys of Shimoga District, Mysore","volume":"11","author":"Work T. H.","year":"1957","unstructured":"T. H.\u00a0Work, H.\u00a0Trapido, Summary of preliminary report of investigations of the Virus Research Centre on an epidemic disease affecting forest villagers and wild monkeys of Shimoga District, Mysore. Indian J.\u00a0Med. Sci. 11, 341\u2013342 (1957).","journal-title":"Indian J.\u00a0Med. Sci."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009678"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001352"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.080759"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58242-w"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai9137"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21428"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1602180"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8030496"},{"key":"e_1_3_2_18_2","first-page":"1659","article-title":"Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques","volume":"81","author":"Raviprakash K.","year":"2000","unstructured":"K.\u00a0Raviprakash, K. R.\u00a0Porter, T. J.\u00a0Kochel, D.\u00a0Ewing, M.\u00a0Simmons, I.\u00a0Phillips, G. S.\u00a0Murphy, W. R.\u00a0Weiss, C. G.\u00a0Hayes, Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques. J. Gen. Virol. 81, 1659\u20131667 (2000).","journal-title":"J. Gen. 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