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In this study, we engineered neutrophil membrane\u2013fused mitochondria (nMITO), which combine the injury-targeting and anti-inflammatory properties of neutrophil membrane proteins with the cell repairing function of mitochondria. nMITO effectively blocked inflammatory cascades and restored mitochondrial function, targeting both key mechanisms in acute organ injuries. In addition, nMITO selectively targeted damaged endothelial cells via \u03b2-integrins and were delivered to injured tissues through tunneling nanotubes, enhancing their regulatory effects on inflammation and cell damage. In mouse models of acute myocardial injury, liver injury, and pancreatitis, nMITO notably reduced inflammatory responses and repaired tissue damage. These findings suggest that nMITO is a promising therapeutic strategy for managing acute organ injuries.<\/jats:p>","DOI":"10.1126\/sciadv.adj1896","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T18:00:13Z","timestamp":1742407213000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["Immunoengineered mitochondria for efficient therapy of acute organ injuries via modulation of inflammation and cell repair"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3179-0829","authenticated-orcid":true,"given":"Qing","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, PR China."},{"name":"Yunnan Key Laboratory of Stem Cell and Regenerative Medicine &amp; Rehabilitation School, Kunming Medical University, Kunming 650500, PR China."},{"name":"Department of 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