{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:39:34Z","timestamp":1787758774810,"version":"build-2784847793"},"reference-count":49,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"51","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:p>\n                    Effective therapies for obesity require invasive surgical and endoscopic interventions or high patient adherence, making it challenging for patients with obesity to effectively manage their disease. Gastric mechanoreceptors sense distension of the stomach and perform volume-dependent vagal signaling to initiate the gastric phase and influence satiety. In this study, we developed a new luminal stimulation modality to specifically activate these gastric stretch receptors to elicit a vagal afferent response commensurate with mechanical distension. We designed the Vibrating Ingestible BioElectronic Stimulator (VIBES) pill, an ingestible device that performs luminal vibratory stimulation to activate mechanoreceptors and stroke mucosal receptors, which induces serotonin release and yields a hormonal metabolic response commensurate with a fed state. We evaluated VIBES across 108 meals in swine which consistently led to diminished food intake (~40%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001) and minimized the weight gain rate (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) as compared to untreated controls. Application of mechanoreceptor biology could transform our capacity to help patients suffering from nutritional disorders.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adj3003","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T13:58:28Z","timestamp":1703253508000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":32,"title":["A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-1324","authenticated-orcid":true,"given":"Shriya S.","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"David H.\u00a0Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Society of Fellows, Harvard University, Cambridge, MA 02138, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-2531","authenticated-orcid":true,"given":"Amro","family":"Alshareef","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."},{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA."},{"name":"David H.\u00a0Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, 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