{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:16:35Z","timestamp":1792206995021,"version":"4.4.0"},"reference-count":85,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,9,20]]},"abstract":"<jats:p>\n                    Sarcopenia is characterized by accelerated muscle mass and function loss, which burdens and challenges public health worldwide. Several studies indicated that selenium deficiency is associated with sarcopenia; however, the specific mechanism remains unclear. Here, we demonstrated that selenoprotein W (SELENOW) containing selenium in the form of selenocysteine functioned in sarcopenia. SELENOW expression is up-regulated in dexamethasone (DEX)\u2013induced muscle atrophy and age-related sarcopenia mouse models. Knockout (KO) of SELENOW profoundly aggravated the process of muscle mass loss in the two mouse models. Mechanistically,\n                    <jats:italic>SELENOW<\/jats:italic>\n                    KO suppressed the RAC1-mTOR cascade by the interaction between SELENOW and RAC1 and induced the imbalance of protein synthesis and degradation. Consistently, overexpression of SELENOW in vivo and in vitro alleviated the muscle and myotube atrophy induced by DEX. SELENOW played a role in age-related sarcopenia and regulated the genes associated with aging. Together, our study uncovered the function of SELENOW in age-related sarcopenia and provides promising evidence for the prevention and treatment of sarcopenia.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adj4122","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T13:58:48Z","timestamp":1726840728000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":45,"title":["Loss of SELENOW aggravates muscle loss with regulation of protein synthesis and the ubiquitin-proteasome system"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6381-7717","authenticated-orcid":true,"given":"Jia-Cheng","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2093-1143","authenticated-orcid":true,"given":"Rong-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-Jian","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tao","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Wuhan 430064, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-0684","authenticated-orcid":true,"given":"Xin Gen","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Cornell University, Ithaca, NY 14853, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-7440","authenticated-orcid":true,"given":"Lv-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328358d59b"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12651"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.051417"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12237"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422413000115"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2226-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2023.12.021"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5313-y"},{"key":"e_1_3_2_11_2","first-page":"689","article-title":"Experimental results with selenium in white muscle disease of lambs and calves","volume":"20","author":"Schubert J. R.","year":"1961","unstructured":"J. R. Schubert, O. H. Muth, J. E. Oldfield, L. F. Remmert, Experimental results with selenium in white muscle disease of lambs and calves. Fed. Proc. 20, 689\u2013694 (1961).","journal-title":"Fed. Proc."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.6.1798"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2022.12.001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51218"},{"key":"e_1_3_2_15_2","first-page":"251","article-title":"Pathology of Keshan disease: A comprehensive review","volume":"96","author":"Gu B. Q.","year":"1983","unstructured":"B. Q. Gu, Pathology of Keshan disease: A comprehensive review. Chinese Med. J. 96, 251\u2013261 (1983).","journal-title":"Chinese Med. J."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.06.014"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.05.026"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-018-1086-7"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196613"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.043"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi602462q"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28385-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1521-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.5.7896009"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(97)00162-9"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3061(00)80142-8"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02628-5"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2006.05.018"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-009-0074-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.07.007"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-009-8367-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.346593"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.09.001"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.152934"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.04.002"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA11502C"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12393"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.054"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.07.004"},{"key":"e_1_3_2_41_2","first-page":"362","article-title":"The mTOR pathway in the control of protein synthesis","volume":"21","author":"Wang X.","year":"2006","unstructured":"X. Wang, C. G. Proud, The mTOR pathway in the control of protein synthesis. Phys. Ther. 21, 362\u2013369 (2006).","journal-title":"Phys. Ther."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.03.017"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110009"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurger.2016.01.003"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12709"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.11.005"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023094"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102761"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020251"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2021.100263"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050440"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115664"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20123-1"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102571"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6317"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251541198"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.12.031"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.005"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112984"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4069"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12532"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0199-y"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr101178k"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091006"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.02.016"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab082"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07858-8"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56688-2_5"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4683"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.16.6019-6029.2000"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00125.2016"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7670"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.10.007"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.05.005"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0134-6"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58500-x"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-018-1288-z"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.2248"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.07.005"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2021.102874"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.02.002"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12560"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.009"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/aro2.51"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.09.029"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2320-y"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adj4122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T13:59:28Z","timestamp":1726840768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adj4122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":85,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2024,9,20]]}},"alternative-id":["10.1126\/sciadv.adj4122"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adj4122","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"2023-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadj4122"}}