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In particular, several extracellular matrix (ECM) proteins are stabilized in the lung under both hypoxia and hyperoxia. Furthermore, we show that complex 1 of the electron transport chain is destabilized in hyperoxia, in accordance with the exacerbation of associated disease models by hyperoxia and rescue by hypoxia. Moreover, we nominate MYBBP1A as a hyperoxia transcriptional regulator, particularly in the context of rRNA homeostasis. Overall, our study highlights the importance of varying oxygen tensions on protein turnover rates and identifies tissue-specific mediators of oxygen-dependent responses.<\/jats:p>","DOI":"10.1126\/sciadv.adj4884","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T13:58:25Z","timestamp":1702043905000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":11,"title":["In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7476-591X","authenticated-orcid":true,"given":"Xuewen","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Disease, Gladstone Institutes, San\u00a0Francisco, CA, USA."},{"name":"Department of Biochemistry and Biophysics, University of California San\u00a0Francisco, San\u00a0Francisco, CA, 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