{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:07:49Z","timestamp":1791925669536,"version":"4.3.4"},"reference-count":66,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"20","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,5,17]]},"abstract":"<jats:p>\n                    Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation by sirtuin 3. We generated an ACSS1-acetylation (Ac) mimic mouse, where lysine-635 was mutated to glutamine (K635Q). Male\n                    <jats:italic>\n                      Acss1\n                      <jats:sup>K635Q\/K635Q<\/jats:sup>\n                    <\/jats:italic>\n                    mice were smaller with higher metabolic rate and blood acetate and decreased liver\/serum ATP and lactate levels. After a 48-hour fast,\n                    <jats:italic>\n                      Acss1\n                      <jats:sup>K635Q\/K635Q<\/jats:sup>\n                    <\/jats:italic>\n                    mice presented hypothermia and liver aberrations, including enlargement, discoloration, lipid droplet accumulation, and microsteatosis, consistent with nonalcoholic fatty liver disease (NAFLD). RNA sequencing analysis suggested dysregulation of fatty acid metabolism, cellular senescence, and hepatic steatosis networks, consistent with NAFLD. Fasted\n                    <jats:italic>\n                      Acss1\n                      <jats:sup>K635Q\/K635Q<\/jats:sup>\n                    <\/jats:italic>\n                    mouse livers showed increased fatty acid synthase (FASN) and stearoyl-CoA desaturase 1 (SCD1), both associated with NAFLD, and increased carbohydrate response element\u2013binding protein binding to\n                    <jats:italic>Fasn<\/jats:italic>\n                    and\n                    <jats:italic>Scd1<\/jats:italic>\n                    enhancer regions. Last, liver lipidomics showed elevated ceramide, lysophosphatidylethanolamine, and lysophosphatidylcholine, all associated with NAFLD. Thus, we propose that ACSS1-K635-Ac dysregulation leads to aberrant lipid metabolism, cellular senescence, and NAFLD.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adj5942","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:59:58Z","timestamp":1715954398000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-6313","authenticated-orcid":true,"given":"Guogang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio, San Antonio, TX, USA."},{"name":"Barshop Institute for Longevity and Aging 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