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A similar heterocercal-to-homocercal transition occurs during teleost ontogeny, although the underlying genetic and developmental mechanisms for either transition remain unresolved. Here, we investigated the role of\n            <jats:italic>hox13<\/jats:italic>\n            genes in caudal fin formation as these genes control posterior identity in animals. Analysis of expression profiles of zebrafish\n            <jats:italic>hox13<\/jats:italic>\n            paralogs and phenotypes of CRISPR\/Cas9-induced mutants showed that double\n            <jats:italic>hoxb13a<\/jats:italic>\n            and\n            <jats:italic>hoxc13a<\/jats:italic>\n            mutants fail to form a caudal fin. Furthermore, single mutants display heterocercal-like morphologies not seen since Mesozoic fossil teleosteomorphs. Relaxation of functional constraints after the teleost genome duplication may have allowed\n            <jats:italic>hox13<\/jats:italic>\n            duplicates to neo- or subfunctionalize, ultimately contributing to the evolution of a homocercal tail in teleost fishes.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adj5991","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T18:58:32Z","timestamp":1705690712000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":21,"title":["<i>Hox<\/i>\n            genes control homocercal caudal fin development and evolution"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-4588","authenticated-orcid":true,"given":"Nicol\u00e1s","family":"Cumplido","sequence":"first","affiliation":[{"name":"Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7363-1319","authenticated-orcid":true,"given":"Gloria","family":"Arratia","sequence":"additional","affiliation":[{"name":"University of Kansas, Department of Ecology and Evolutionary Biology and Biodiversity Institute, Lawrence, KS, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-8785","authenticated-orcid":true,"given":"Thomas","family":"Desvignes","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, University of Oregon, Eugene, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2845-6841","authenticated-orcid":true,"given":"Salom\u00e9","family":"Mu\u00f1oz-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-2137","authenticated-orcid":true,"given":"John H.","family":"Postlethwait","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, University of Oregon, Eugene, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-2152","authenticated-orcid":true,"given":"Miguel L.","family":"Allende","sequence":"additional","affiliation":[{"name":"Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"143","article-title":"\u00dcber das Wirbels\u00e4ulen-Ende bei Ganoiden und Teleostiern","volume":"5","author":"Heckel J. 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