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We electrically stimulated the three peripheral dermatomes of the trigemino-cervical complex and the greater occipital nerve in 61 humans during optimized brainstem functional magnetic resonance imaging. We provide evidence for a fine-grained and highly specific somatotopic representation of nociceptive input in the PAG in humans and a functional connectivity between the individual representations of the peripheral nerves in the PAG and the brainstem nuclei of these nerves. Our data suggest that the downstream antinociceptive properties of the PAG may be rather specific down to the level of individual dermatomes.<\/jats:p>","DOI":"10.1126\/sciadv.adj8213","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T17:59:03Z","timestamp":1710957543000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Functional representation of trigeminal nociceptive input in the human periaqueductal gray"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-740X","authenticated-orcid":true,"given":"Jan","family":"Mehnert","sequence":"first","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Eppendorf, 20146 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-0201","authenticated-orcid":true,"given":"Alexandra","family":"Tinnermann","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Eppendorf, 20146 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-0172","authenticated-orcid":true,"given":"Hauke","family":"Basedau","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Eppendorf, 20146 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1506","authenticated-orcid":true,"given":"Arne","family":"May","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Eppendorf, 20146 Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","unstructured":"M. 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