{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:37:22Z","timestamp":1790890642946,"version":"4.1.0"},"reference-count":82,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"47","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2023,11,24]]},"abstract":"<jats:p>\n                    Gastric cancer (GC) with peritoneal metastases and malignant ascites continues to have poor prognosis. Exosomes mediate intercellular communication during cancer progression and promote therapeutic resistance. Here, we report the significance of exosomes derived from malignant ascites (EXO\n                    <jats:sup>Ascites<\/jats:sup>\n                    ) in cancer progression and use modified exosomes as resources for cancer therapy. EXO\n                    <jats:sup>Ascites<\/jats:sup>\n                    from patients with GC stimulated invasiveness and angiogenesis in an ex vivo three-dimensional autologous tumor spheroid microfluidic system. EXO\n                    <jats:sup>Ascites<\/jats:sup>\n                    concentration increased invasiveness, and blockade of their secretion suppressed tumor progression. In\n                    <jats:italic>MET<\/jats:italic>\n                    -amplified GC, EXO\n                    <jats:sup>Ascites<\/jats:sup>\n                    contain abundant MET; their selective delivery to tumor cells enhanced angiogenesis and invasiveness. Exosomal MET depletion substantially reduced invasiveness; an additive therapeutic effect was induced when combined with MET and\/or VEGFR2 inhibition in a patient-derived\n                    <jats:italic>MET<\/jats:italic>\n                    -amplified GC model. Allogeneic MET-harboring exosome delivery induced invasion and angiogenesis in a\n                    <jats:italic>MET<\/jats:italic>\n                    non-amplified GC model.\n                    <jats:italic>MET<\/jats:italic>\n                    -amplified patient tissues showed higher exosome concentration than their adjacent normal tissues. Manipulating exosome content and production may be a promising complementary strategy against GC.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adk1098","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T13:58:15Z","timestamp":1700834295000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":47,"title":["Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancer"],"prefix":"10.1126","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-0972","authenticated-orcid":true,"given":"Sujin","family":"Hyung","sequence":"first","affiliation":[{"name":"Precision Medicine Research Institute, Samsung Medical Center, Seoul, Republic of Korea."},{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-3728","authenticated-orcid":true,"given":"Jihoon","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of BioNano Technology, Gachon University, Gyeonggi 13120, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-711X","authenticated-orcid":true,"given":"You Jeong","family":"Heo","sequence":"additional","affiliation":[{"name":"Neocella Inc., Irvine, CA 92606, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6030-7192","authenticated-orcid":true,"given":"Steven M.","family":"Blum","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology-Oncology, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7335-1846","authenticated-orcid":true,"given":"Seung Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-2612","authenticated-orcid":true,"given":"Joon Oh","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-8086","authenticated-orcid":true,"given":"Won Ki","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yeong","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4062-0808","authenticated-orcid":true,"given":"Samuel J.","family":"Klempner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology-Oncology, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-6165","authenticated-orcid":true,"given":"Jeeyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s10038-021-00960-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101404"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00326-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2021.02.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9683"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20429-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00240-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1080"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1446"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v7.i11.317"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2022.1610697"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2530"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3169"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15756"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0250-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.01.033"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj7002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba5714"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb6981"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.17"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01305-4"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1001-7"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0967-5"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i39.10936"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41525-021-00212-w"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-015-0523-y"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15016"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2753"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03224-w"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgy115"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.10.020"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.05.004"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9070522"},{"key":"e_1_3_2_38_2","first-page":"2210","article-title":"Exosome mediated multidrug resistance in cancer","volume":"8","author":"Yousafzai N. A.","year":"2018","unstructured":"N. A.\u00a0Yousafzai, H.\u00a0Wang, Z.\u00a0Wang, Y.\u00a0Zhu, L.\u00a0Zhu, H.\u00a0Jin, X.\u00a0Wang, Exosome mediated multidrug resistance in cancer. Am. J.\u00a0Cancer Res. 8, 2210\u20132226 (2018).","journal-title":"Am. J.\u00a0Cancer Res."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310501111"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0349-5","article-title":"Recent progress in mapping the emerging landscape of the small-cell lung cancer genome","volume":"51","author":"Kim K.-B.","year":"2019","unstructured":"K.-B.\u00a0Kim, C. T.\u00a0Dunn, K.-T.\u00a0Park, Recent progress in mapping the emerging landscape of the small-cell lung cancer genome. Exp. Mol. Med. 51, 1\u201313 (2019).","journal-title":"Exp. Mol. Med."},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-018-0049-3"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1754814"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15287"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71573-y"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.05.034"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.10.022"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0333-4"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2019-0231"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat5690"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22341"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01433-3"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01555-x"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.134"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S231257"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00164"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx134"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02047-3"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09681-3"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv081"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aar2766"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133305"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200562"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2664"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0060-4"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz2083"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-0573-0"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39434"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0036-9"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S231214"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.05.036"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1319044"},{"key":"e_1_3_2_72_2","first-page":"791","article-title":"Neoantigens and Whole-Exome Sequencing","volume":"43","author":"Karasaki T.","year":"2016","unstructured":"T.\u00a0Karasaki, J.\u00a0Nakajima, K.\u00a0Kakimi, Neoantigens and Whole-Exome Sequencing. Gan To Kagaku Ryoho 43, 791\u2013797 (2016).","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27031"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7253-1_3"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4259"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31304"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2058-y"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508776103"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00140A"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00276"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10859"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.108"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12143"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adk1098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T17:14:47Z","timestamp":1704820487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adk1098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,24]]},"references-count":82,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2023,11,24]]}},"alternative-id":["10.1126\/sciadv.adk1098"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adk1098","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,24]]},"assertion":[{"value":"2023-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadk1098"}}