{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:06:51Z","timestamp":1790363211247,"version":"4.1.0"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"11","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:p>\n            Muscle contraction is a regulated process driven by the sliding of actin-thin filaments over myosin-thick filaments. Lmod2 is an actin filament length regulator and essential for life since human mutations and complete loss of Lmod2 in mice lead to dilated cardiomyopathy and death. To study the little-known role of Lmod2 in skeletal muscle, we created a mouse model with Lmod2 expressed exclusively in the heart but absent in skeletal muscle. Loss of Lmod2 in skeletal muscle results in decreased force production in fast- and slow-twitch muscles. Soleus muscle from rescued\n            <jats:italic>Lmod2<\/jats:italic>\n            knockout mice have shorter thin filaments, increased Lmod3 levels, and present with a myosin fiber type switch from fast myosin heavy chain (MHC) IIA to the slower MHC I isoform. Since Lmod2 regulates thin-filament length in slow-twitch but not fast-twitch skeletal muscle and force deficits were observed in both muscle types, this work demonstrates that Lmod2 regulates skeletal muscle contraction, independent of its role in thin-filament length regulation.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adk1890","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T18:02:34Z","timestamp":1710352954000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":16,"title":["Lmod2 is necessary for effective skeletal muscle contraction"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-1808","authenticated-orcid":true,"given":"Tania M.","family":"Larrinaga","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrie P.","family":"Farman","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-1147","authenticated-orcid":true,"given":"Rachel M.","family":"Mayfield","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5007-4548","authenticated-orcid":true,"given":"Michaela","family":"Yuen","sequence":"additional","affiliation":[{"name":"Kids Neuroscience Centre, Kids Research, The Children\u2019s Hospital at Westmead, Sydney, NSW 2145, Australia."},{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia."},{"name":"The Children\u2019s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8243-7123","authenticated-orcid":true,"given":"Rebecca C.","family":"Ahrens-Nicklas","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-5097","authenticated-orcid":true,"given":"Sandra T.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Kids Neuroscience Centre, Kids Research, The Children\u2019s Hospital at Westmead, Sydney, NSW 2145, Australia."},{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia."},{"name":"The Children\u2019s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-6949","authenticated-orcid":true,"given":"Christopher T.","family":"Pappas","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-2074","authenticated-orcid":true,"given":"Carol C.","family":"Gregorio","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA."},{"name":"Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, 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