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We describe a thermoresponsive, antioxidant macromolecule poly(polyethylene glycol citrate-\n                    <jats:italic>co<\/jats:italic>\n                    -\n                    <jats:italic>N<\/jats:italic>\n                    -isopropylacrylamide) (PPCN) to protect islet redox status and function and to enable extrahepatic omentum islet engraftment. PPCN solution transitions from a liquid to a hydrogel at body temperature. Islets entrapped in PPCN and exposed to oxidative stress remain functional and support long-term euglycemia, in contrast to islets entrapped in a plasma-thrombin biologic scaffold. In the nonhuman primate (NHP) omentum, PPCN is well-tolerated and mostly resorbed without fibrosis at 3 months after implantation. In NHPs, autologous omentum islet transplantation using PPCN restores normoglycemia with minimal exogenous insulin requirements for &gt;100 days. This preclinical study supports TP-IAT with PPCN in patients with CP and highlights antioxidant properties as a mechanism for islet function preservation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adk3081","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T13:58:50Z","timestamp":1717768730000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-2123","authenticated-orcid":true,"given":"Jacqueline A.","family":"Burke","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA."},{"name":"Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, 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