{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:27:02Z","timestamp":1792441622234,"version":"4.5.0"},"reference-count":126,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"35","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,8,30]]},"abstract":"<jats:p>The mammalian retina is considered an autonomous circuit, yet work dating back to Ramon y Cajal indicates that it receives inputs from the brain. How such inputs affect retinal processing has remained unknown. We confirmed brain-to-retina projections of histaminergic neurons from the mouse hypothalamus. Histamine application ex vivo altered the activity of various retinal ganglion cells (RGCs), including direction-selective RGCs that gained responses to high motion velocities. These results were reproduced in vivo with optic tract recordings where histaminergic retinopetal axons were activated chemogenetically. Such changes could improve vision of fast-moving objects (e.g., while running), which fits with the known increased activity of histaminergic neurons during arousal. An antihistamine drug reduced optomotor responses to high-speed moving stimuli in freely moving mice. In humans, the same antihistamine nonuniformly modulated visual sensitivity across the visual field, indicating an evolutionary conserved function of the histaminergic system. Our findings expose a previously unappreciated role for brain-to-retina projections in modulating retinal function.<\/jats:p>","DOI":"10.1126\/sciadv.adk4062","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T14:01:55Z","timestamp":1724853715000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5621-6301","authenticated-orcid":true,"given":"Rebekah A.","family":"Warwick","sequence":"first","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-4586","authenticated-orcid":true,"given":"Serena","family":"Riccitelli","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-1581","authenticated-orcid":true,"given":"Alina S.","family":"Heukamp","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1769-2221","authenticated-orcid":true,"given":"Hadar","family":"Yaakov","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6634-086X","authenticated-orcid":true,"given":"Bani Prasad","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-6239","authenticated-orcid":true,"given":"Lea","family":"Ankri","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2237-3880","authenticated-orcid":true,"given":"Jonathan","family":"Mayzel","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Gilead","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reut","family":"Parness-Yossifon","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Kaplan Medical Center, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-6270","authenticated-orcid":true,"given":"Stefano","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy."},{"name":"IRCCS Ospedale Policlinico San Martino, Genova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-3370","authenticated-orcid":true,"given":"Michal","family":"Rivlin-Etzion","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","first-page":"1","article-title":"Estructura de los centros nerviosos de las aves","volume":"1","author":"Cajal S. R.","year":"1888","unstructured":"S. R. y Cajal, Estructura de los centros nerviosos de las aves. Rev. Trim. Histol. Norm. Patol 1, 1\u201310 (1888).","journal-title":"Rev. Trim. Histol. Norm. Patol"},{"key":"e_1_3_2_3_2","first-page":"111","article-title":"Sur la morphologie etles connexions de lar\u00e9tine des oiseaux","volume":"4","author":"Cajal S. R.","year":"1889","unstructured":"S. R. y Cajal, Sur la morphologie etles connexions de lar\u00e9tine des oiseaux. Anat. Anz. 4, 111\u2013128 (1889).","journal-title":"Anat. Anz."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)60874-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-08-02025.1984"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90006-X"},{"key":"e_1_3_2_7_2","first-page":"487","article-title":"Histamine immunoreactive axons in the macaque retina","volume":"40","author":"Gastinger M. J.","year":"1999","unstructured":"M. J. Gastinger, J. J. O\u2019Brien, N. B. Larsen, D. W. Marshak, Histamine immunoreactive axons in the macaque retina. Invest. Ophthalmol. Vis. Sci. 40, 487\u2013495 (1999).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_2_8_2","first-page":"2679","article-title":"Abnormal centrifugal axons in streptozotocin-diabetic rat retinas","volume":"42","author":"Gastinger M. J.","year":"2001","unstructured":"M. J. Gastinger, A. J. Barber, S. A. Khin, C. S. McRill, T. W. Gardner, D. W. Marshak, Abnormal centrifugal axons in streptozotocin-diabetic rat retinas. Invest. Ophthalmol. Vis. Sci. 42, 2679\u20132685 (2001).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.034"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0940.1000216"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730204"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960916)373:2<271::AID-CNE9>3.0.CO;2-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2572"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90811-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680600776119"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(88)90108-8"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01969038"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1034"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6160"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20902"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0542-9"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22731"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0278-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2746"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4806"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523804216133"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2007"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy183"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2341-06.2006"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(03)00091-3"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.04.026"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.07.065"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-01098.2002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.003"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3359-13.2014"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.01.016"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903250302"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.11.006"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.054"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0471-20.2020"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-14-06063.2003"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523809990137"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.002"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.012"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.014"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700293104"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003020"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4197"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2778-13.2013"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078058"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00055.2017"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.00980050100017"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.04.005"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60064-1"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90034-R"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.10.045"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06780-3"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3689-16.2017"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.033"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7893"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.028"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1854-19.2019"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0430-16.2016"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.05.045"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00227.2016"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03130.2003"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3749-04.2004"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.03.043"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12499"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.075"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23635"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-091517-034048"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107608"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan2475"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41088-2"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.1.1"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/35048583"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpaic.2017.01.007"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.52.3.245"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1982.tb04957.x"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00542129"},{"key":"e_1_3_2_82_2","article-title":"Integrated multi-omics single cell atlas of the human retina","author":"Li J.","year":"2023","unstructured":"J. Li, J. Wang, I. L. Ibarra, X. Cheng, M. D. Luecken, J. Lu, A. Monavarfeshani, W. Yan, Y. Zheng, Z. Zuo, S. L. Z. Colborn, B. S. Cortez, L. A. Owen, N. M. Tran, K. Shekhar, J. R. Sanes, J. T. Stout, S. Chen, Y. Li, M. M. DeAngelis, F. J. Theis, R. Chen, Integrated multi-omics single cell atlas of the human retina. Res. Sq. (2023) doi: 10.21203\/rs.3.rs-3471275\/v1.","journal-title":"Res. Sq."},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.004"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90046-0"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(90)90035-D"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90364-2"},{"key":"e_1_3_2_87_2","first-page":"719","article-title":"Retinal afferents of hypothalamic origin in a prosimian primate: Microcebus murinus. Study using retrograde fluorescent tracers","volume":"303","author":"Bons N.","year":"1986","unstructured":"N. Bons, A. Petter, Retinal afferents of hypothalamic origin in a prosimian primate: Microcebus murinus. Study using retrograde fluorescent tracers. C. R. Acad. Sci. III 303, 719\u2013722 (1986).","journal-title":"C. R. Acad. Sci. III"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90082-4"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1985.tb06828.x"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90263-0"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90086-4"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237991"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90318-4"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)90369-4"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800006738"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02706-2"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680500371532"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0564-11.2011"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108697"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2931-12.2012"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2707-07.2007"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02033"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.106"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3075-20.2021"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00357"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856897X00366"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1241-13.2013"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_3_2_111_2","doi-asserted-by":"crossref","unstructured":"M. Pachitariu N. Steinmetz S. Kadir M. Carandini K. D. Harris Kilosort: Realtime spike-sorting for extracellular electrophysiology with hundreds of channels. bioRxiv 061481 [Preprint] (2016). https:\/\/doi.org\/10.1101\/061481.","DOI":"10.1101\/061481"},{"key":"e_1_3_2_112_2","unstructured":"M. Pachitariu N. A. Steinmetz J. Colonell Kilosort2 (2018); https:\/\/github.com\/MouseLand\/."},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4268"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00036"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1323"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24636"},{"key":"e_1_3_2_117_2","doi-asserted-by":"crossref","unstructured":"P. Shamash M. Carandini K. D. Harris N. A. Steinmetz A tool for analyzing electrode tracks from slice histology. bioRxiv 10.1101\/447995 (2018).","DOI":"10.1101\/447995"},{"key":"e_1_3_2_118_2","unstructured":"SCP Broad Institute Single cell portal; https:\/\/singlecell.broadinstitute.org\/single_cell."},{"key":"e_1_3_2_119_2","unstructured":"HCA Data Explorer The human cell atlas; https:\/\/data.humancellatlas.org\/."},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111322"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111040"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06659-4"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.08.007"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31368-3"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(92)90297-F"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188572"},{"key":"e_1_3_2_127_2","unstructured":"A. Penn MATLAB Central File Exchange wanova (2021); https:\/\/mathworks.com\/matlabcentral\/fileexchange\/61661-wanova."}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.adk4062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T14:03:19Z","timestamp":1724853799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adk4062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":126,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2024,8,30]]}},"alternative-id":["10.1126\/sciadv.adk4062"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.adk4062","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.26.489509","asserted-by":"object"}]},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eadk4062"}}