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Mechanistically, PRCAT71 acts as a scaffold to recruit K homology (KH)\u2013type splicing regulatory protein (KHSRP) to AR messenger RNA (mRNA) and stabilize AR mRNA, leading to activated AR signaling. KHSRP plays a critical role in PCa progression. PRCAT71 is transcriptionally regulated by AR-driven enhancers, forming a positive regulatory loop between AR and PRCAT71 in PCa. Our study demonstrates a coordinated regulation of AR mRNA by lncRNA PRCAT71 and RNA binding protein KHSRP and provides insight that the PRCAT71-KHSRP-AR axis is a promising therapeutic target for treating PCa.<\/jats:p>","DOI":"10.1126\/sciadv.adk6989","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:58:41Z","timestamp":1744207121000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Androgen receptor\u2013regulated lncRNA PRCAT71 promotes AR signaling through the interaction with KHSRP in prostate cancer"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5848","authenticated-orcid":true,"given":"Yongyong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, 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