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Here, we present continuous measurements of local IOP values in the anterior chamber and vitreous chamber of living animals using minimally invasive probes with pressure-sensitive transistors. After inducing glaucoma in animal models, we compared the local IOP distribution between normal and glaucomatous eyes. We also compared IOP values detected in the cornea using tonometry measurements. Our findings revealed that glaucoma induced higher IOP in the vitreous chamber than in the anterior chamber, indicating that measuring IOP in the vitreous chamber is key to the glaucoma model. This progress offers future directions for diagnosis and treatment of glaucoma.<\/jats:p>","DOI":"10.1126\/sciadv.adk7805","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T14:36:41Z","timestamp":1707316601000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":34,"title":["Real-time in vivo monitoring of intraocular pressure distribution in the anterior chamber and vitreous chamber for diagnosis of glaucoma"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1509-9766","authenticated-orcid":true,"given":"Hunkyu","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea."},{"name":"Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-1275","authenticated-orcid":true,"given":"Yeon-Mi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea."},{"name":"Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-8492","authenticated-orcid":true,"given":"Won Gi","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea."},{"name":"Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-8097","authenticated-orcid":true,"given":"Wonjung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea."},{"name":"Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-7361","authenticated-orcid":true,"given":"Jakyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea."},{"name":"Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-3506","authenticated-orcid":true,"given":"Hong Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-0830","authenticated-orcid":true,"given":"Suk Ho","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-5092","authenticated-orcid":true,"given":"Dai Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-4958","authenticated-orcid":true,"given":"Jang-Ung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea."},{"name":"Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea."},{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea."},{"name":"Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000354"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.2.23"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.67"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17179-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"Z. 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