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This resulted in sex-biased brain microstructural, functional, and behavioral alterations, resembling those of ex-preterm children, which we characterized performing parallel mouse\/human behavioral tests. Pharmacological enhancement of GABAergic tonic inhibition by the U.S. Food and Drug Administration\u2013approved drug ganaxolone rescued functional\/behavioral alterations in mice. Establishing an unprecedented mouse model of prematurity, our work dissects the mechanisms at the core of abnormal behaviors and identifies a readily translatable therapeutic strategy for preterm brain disorders.<\/jats:p>","DOI":"10.1126\/sciadv.adk8123","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T18:58:56Z","timestamp":1709319536000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":18,"title":["Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0568-9774","authenticated-orcid":true,"given":"Alberto","family":"Potenzieri","sequence":"first","affiliation":[{"name":"Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy."},{"name":"Universit\u00e0 degli Studi di Genova, via Balbi, 5, 16126 Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Uccella","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy."},{"name":"Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy."},{"name":"Patologia Neonatale, IRCCS Istituto Giannina Gaslini, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1956-0482","authenticated-orcid":true,"given":"Deborah","family":"Preiti","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy."},{"name":"Patologia Neonatale, IRCCS Istituto Giannina Gaslini, Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-5220","authenticated-orcid":true,"given":"Matteo","family":"Pisoni","sequence":"additional","affiliation":[{"name":"Optical Approaches to Brain Function Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rosati","sequence":"additional","affiliation":[{"name":"Brain Development and Disease Laboratory, Istituto Italiano di Tecnologia, via Morego, 30, 16163 Genoa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5543-5285","authenticated-orcid":true,"given":"Chiara","family":"Lavarello","sequence":"additional","affiliation":[{"name":"Core Facilities - 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