{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:01:42Z","timestamp":1791669702576,"version":"4.3.4"},"reference-count":63,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"14","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,4,5]]},"abstract":"<jats:p>\n                    The dynamin-related guanosine triphosphatase, Drp1 (encoded by\n                    <jats:italic toggle=\"yes\">Dnm1l<\/jats:italic>\n                    ), plays a central role in mitochondrial fission and is requisite for numerous cellular processes; however, its role in muscle metabolism remains unclear. Here, we show that, among human tissues, the highest number of gene correlations with\n                    <jats:italic toggle=\"yes\">DNM1L<\/jats:italic>\n                    is in skeletal muscle. Knockdown of Drp1 (Drp1-KD) promoted mitochondrial hyperfusion in the muscle of male mice. Reduced fatty acid oxidation and impaired insulin action along with increased muscle succinate was observed in Drp1-KD muscle. Muscle Drp1-KD reduced complex II assembly and activity as a consequence of diminished mitochondrial translocation of succinate dehydrogenase assembly factor 2 (Sdhaf2). Restoration of Sdhaf2 normalized complex II activity, lipid oxidation, and insulin action in Drp1-KD myocytes. Drp1 is critical in maintaining mitochondrial complex II assembly, lipid oxidation, and insulin sensitivity, suggesting a mechanistic link between mitochondrial morphology and skeletal muscle metabolism, which is clinically relevant in combatting metabolic-related diseases.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adl0389","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:58:27Z","timestamp":1712152707000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":22,"title":["Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-9704","authenticated-orcid":true,"given":"Zhenqi","family":"Zhou","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, Los 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