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Here, we comprehensively investigated FOXL2\u2019s role through a multi-omics approach to characterize gene expression dynamics and chromatin accessibility changes, coupled with genome-wide identification of FOXL2 targets and on-chromatin interacting partners in somatic cells across ovarian development. We found that FOXL2 regulates more targets postnatally, through interaction with factors regulating primordial follicle formation and steroidogenesis. Deletion of one interactor, ubiquitin-specific protease 7 (\n                    <jats:italic>Usp7<\/jats:italic>\n                    ), results in impairment of somatic cell differentiation, germ cell nest breakdown, and ovarian development, leading to sterility. Our datasets constitute a comprehensive resource for exploration of the molecular mechanisms of ovarian development and causes of female infertility.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adl0788","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T13:58:43Z","timestamp":1711115923000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":29,"title":["FOXL2 interaction with different binding partners regulates the dynamics of ovarian development"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-1060","authenticated-orcid":true,"given":"Roberta","family":"Migale","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cell Biology and Developmental Genetics, The Francis Crick Institute, London NW1 1AT, 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