{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:43:36Z","timestamp":1792089816598,"version":"4.4.0"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"10","content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2024,3,8]]},"abstract":"<jats:p>\n            Coxsackievirus B (CVB) infection of pancreatic \u03b2 cells is associated with \u03b2 cell autoimmunity and type 1 diabetes. We investigated how CVB affects human \u03b2 cells and anti-CVB T cell responses. \u03b2 cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8\n            <jats:sup>+<\/jats:sup>\n            T cells from CVB\u2013seropositive individuals recognized a fraction of these peptides; only another subfraction was targeted by effector\/memory T cells that expressed exhaustion marker PD-1. T cells recognizing a CVB epitope cross-reacted with \u03b2 cell antigen GAD. Infected \u03b2 cells, which formed filopodia to propagate infection, were more efficiently killed by CVB than by CVB-reactive T cells. Our in vitro and ex vivo data highlight limited CD8\n            <jats:sup>+<\/jats:sup>\n            T cell responses to CVB, supporting the rationale for CVB vaccination trials for type 1 diabetes prevention. CD8\n            <jats:sup>+<\/jats:sup>\n            T cells recognizing structural and nonstructural CVB epitopes provide biomarkers to differentially follow response to infection and vaccination.\n          <\/jats:p>","DOI":"10.1126\/sciadv.adl1122","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T18:58:51Z","timestamp":1709751531000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Coxsackievirus infection induces direct pancreatic \u03b2 cell killing but poor antiviral CD8\n            <sup>+<\/sup>\n            T cell responses"],"prefix":"10.1126","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-8818","authenticated-orcid":true,"given":"Federica","family":"Vecchio","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institut Cochin, CNRS, INSERM, Paris, 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